Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 6/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952389 | 0.81 | SLC2A1 (0.34) | IMPDH2SLC2A1SHMT2 | |
| SCHEMBL9928964 | 0.78 | ADRB2 (0.39) | ADRB2ADRB1IMPDH2CYP1A2SLC22A3 | |
| SCHEMBL9952243 | 0.77 | IMPDH2 (0.36) | IMPDH2SLC2A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9952473 | 0.75 | IMPDH2 (0.41) | IMPDH2SLC2A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9952754 | 0.75 | IMPDH2 (0.42) | IMPDH2SLC2A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL17138431 | 0.74 | ADRB2 (0.37) | ADRB2ADRB1SLC22A3ADRB3KDM4E | |
| SCHEMBL14736249 | 0.72 | IMPDH2 (0.37) | IMPDH2KDM4EMEN1GAAKMT2A | |
| SCHEMBL9952391 | 0.71 | SLC2A1 (0.34) | IMPDH2SLC2A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9952992 | 0.70 | IMPDH2 (0.37) | IMPDH2SLC2A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9952270 | 0.68 | REN (0.31) | SLC2A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |