Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952271 | 0.85 | IMPDH2 (0.30) | IMPDH2 | |
| SCHEMBL17138393 | 0.81 | NPC1 (0.31) | ALDH1A1NPC1HTTRAB9APAX8 | |
| SCHEMBL9952238 | 0.81 | ADRB2 (0.36) | SLC2A1IMPDH2SHMT2 | |
| SCHEMBL9952391 | 0.77 | SLC2A1 (0.34) | SLC2A1IMPDH2NPC1RAB9APAX8 | |
| SCHEMBL9929011 | 0.76 | — | — | |
| SCHEMBL9952473 | 0.71 | IMPDH2 (0.41) | SLC2A1IMPDH2ALDH1A1SHMT2 | |
| SCHEMBL9952243 | 0.71 | IMPDH2 (0.36) | SLC2A1IMPDH2ALDH1A1SHMT2 | |
| SCHEMBL9952754 | 0.71 | IMPDH2 (0.42) | SLC2A1IMPDH2ALDH1A1SHMT2 | |
| SCHEMBL9952992 | 0.66 | IMPDH2 (0.37) | SLC2A1IMPDH2ALDH1A1HTTSHMT2 | |
| SCHEMBL14736249 | 0.64 | IMPDH2 (0.37) | IMPDH2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |