Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | GPX4 | P36969 | 1/20 | 0.30 |
| ▸ | YAP1 | P46937 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.30 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952243 | 0.82 | IMPDH2 (0.36) | SLC2A1IMPDH2SHMT2MEN1KMT2A | |
| SCHEMBL9952389 | 0.77 | SLC2A1 (0.34) | SLC2A1IMPDH2SHMT2NPC1RAB9A | |
| SCHEMBL9952473 | 0.72 | IMPDH2 (0.41) | SLC2A1IMPDH2SHMT2MEN1KMT2A | |
| SCHEMBL9952754 | 0.72 | IMPDH2 (0.42) | SLC2A1IMPDH2SHMT2MEN1KMT2A | |
| SCHEMBL9952238 | 0.71 | ADRB2 (0.36) | SLC2A1IMPDH2SHMT2MEN1KMT2A | |
| SCHEMBL9952992 | 0.69 | IMPDH2 (0.37) | SLC2A1IMPDH2SHMT2MEN1KMT2A | |
| SCHEMBL9952863 | 0.65 | MTNR1A (0.38) | SLC2A1IMPDH2SHMT2MEN1KMT2A | |
| SCHEMBL20446650 | 0.64 | SHMT2 (0.52) | SHMT2MEN1KMT2ALMNAMAPT | |
| SCHEMBL9952618 | 0.64 | P2RX7 (0.37) | SLC2A1IMPDH2SHMT2KMT2ANPC1 | |
| SCHEMBL9952271 | 0.62 | IMPDH2 (0.30) | IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |