Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952656 | 0.81 | IMPDH2 (0.34) | IMPDH2KDM4EALDH1A1GAA | |
| SCHEMBL9952473 | 0.78 | IMPDH2 (0.41) | IMPDH2SHMT2SLC2A1MTNR1AMTNR1B | |
| SCHEMBL9952618 | 0.78 | P2RX7 (0.37) | IMPDH2SHMT2SLC2A1KMT2ADRD2 | |
| SCHEMBL9952863 | 0.77 | MTNR1A (0.38) | IMPDH2SHMT2SLC2A1MTNR1AMTNR1B | |
| SCHEMBL9952754 | 0.75 | IMPDH2 (0.42) | IMPDH2SHMT2SLC2A1MTNR1AMTNR1B | |
| SCHEMBL9952989 | 0.73 | PIK3CD (0.41) | IMPDH2KDM4EALDH1A1GAA | |
| SCHEMBL9952766 | 0.71 | DRD3 (0.33) | SHMT2SLC2A1MTNR1AMTNR1BMEN1 | |
| SCHEMBL9952243 | 0.70 | IMPDH2 (0.36) | IMPDH2SHMT2SLC2A1MTNR1AMTNR1B | |
| SCHEMBL14742364 | 0.70 | PIK3CD (0.48) | IMPDH2 | |
| SCHEMBL9952238 | 0.70 | ADRB2 (0.36) | IMPDH2SHMT2SLC2A1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |