Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPD | P32754 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 3/20 | 0.40 |
| ▸ | IDO2 | Q6ZQW0 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952904 | 0.88 | GLA (0.51) | POLBGLATDO2IDO2IDO1 | |
| SCHEMBL9954358 | 0.88 | ALDH1A1 (0.53) | HPDPOLBTDO2IDO2ALDH1A1 | |
| SCHEMBL9953501 | 0.86 | HPD (0.47) | HPDPOLBGLATDO2IDO2 | |
| SCHEMBL9954671 | 0.85 | HCAR1 (0.52) | HPDGLATDO2IDO2HCAR1 | |
| SCHEMBL9953564 | 0.83 | TDO2 (0.48) | HPDPOLBGLATDO2IDO2 | |
| SCHEMBL9954001 | 0.79 | PDE4D (0.56) | HPDALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL9953800 | 0.79 | POLB (0.41) | POLBHCAR1PI4KAPIK3CGCA12 | |
| SCHEMBL9954505 | 0.78 | PDE7A (0.45) | TDO2IDO2MAPTHCAR1PI4KA | |
| SCHEMBL9954423 | 0.76 | POLB (0.41) | POLBTDO2IDO2IDO1PI4KA | |
| SCHEMBL9954651 | 0.76 | POLB (0.53) | HPDPOLBTDO2IDO2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |