Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 6/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953497 | 0.92 | PDE4D (0.43) | HCAR1PDE4DCA12CA1CA2 | |
| SCHEMBL9954224 | 0.88 | CDK9 (0.38) | HCAR1EPHB4PDE4DCA12CA1 | |
| SCHEMBL9954005 | 0.82 | HCAR1 (0.40) | HCAR1PDE4DCA12CA1CA2 | |
| SCHEMBL9954001 | 0.81 | PDE4D (0.56) | HCAR1PDE4DCA12CA1CA2 | |
| SCHEMBL9954747 | 0.81 | HCAR1 (0.53) | HCAR1 | |
| SCHEMBL9954505 | 0.79 | PDE7A (0.45) | HCAR1PDE4DDYRK1API4KATDO2 | |
| SCHEMBL9953324 | 0.76 | HCAR1 (0.50) | HCAR1CA12CA1CA2CA9 | |
| SCHEMBL9953800 | 0.75 | POLB (0.41) | HCAR1PDE4DCA12CA1CA2 | |
| SCHEMBL9954358 | 0.75 | ALDH1A1 (0.53) | HCAR1PDE4DCA12CA1CA2 | |
| SCHEMBL9953432 | 0.73 | HCAR1 (0.55) | HCAR1PDE4DTDO2IDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |