Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13088390 | 0.83 | LMNA (0.47) | SMN1; SMN2ALDH1A1LMNATLR8TLR7 | |
| SCHEMBL10325225 | 0.79 | TLR8 (0.53) | SMN1; SMN2ALDH1A1GABRA1GABRB1GABRA3 | |
| SCHEMBL3567927 | 0.79 | TSHR (0.49) | ALDH1A1GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL13088391 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL25229975 | 0.78 | KDM4E (0.36) | ALDH1A1TLR8TLR7MEN1MAPT | |
| SCHEMBL5209600 | 0.78 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1GABRA1GABRB1GABRA3 | |
| Hydrochloric Acid SCHEMBL3567925 | 0.78 | TSHR (0.47) | ALDH1A1GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL19398238 | 0.78 | TLR8 (0.49) | SMN1; SMN2ALDH1A1GABRA1GABRB1GABRA3 | |
| SCHEMBL3093660 | 0.77 | SRD5A1 (0.40) | SMN1; SMN2ALDH1A1LMNAMEN1MAPT | |
| SCHEMBL3032882 | 0.77 | TLR8 (0.61) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785489-B2 | Heteroaryl substituted indole compounds useful as MMP-13 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-22 | — | — | US | disclosed |
| US-20120157425-A1 | NEW COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-21 | — | — | US | disclosed |
| US-20110275631-A1 | Heteroaryl Substituted Indole Compounds Useful as MMP-13 Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157425-A1 | NEW COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | P2RX5, P2RX3, ABCG2 | SMN1; SMN2 4388/4885ALDH1A1 388/4885GABRA1 623/4885 |
| US-20110275631-A1 | Heteroaryl Substituted Indole Compounds Useful as MMP-13 Inhibitors | MMP13, MMP3, MMP11 | SMN1; SMN2 4073/4885ALDH1A1 311/4885GABRA1 3918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.