Sugi Predict

Sugi Predict / Compounds / SCHEMBL9967737

SCHEMBL9967737

SCHEMBL9967737

CC(C)c1ccc(Cl)cc1Br

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.47
▸ HTT P42858 2/20 0.47
▸ TP53 P04637 2/20 0.47
▸ GABRA1 P14867 2/20 0.41
▸ GABRB1 P18505 2/20 0.41
▸ KCNH2 Q12809 2/20 0.36
▸ PARP1 P09874 1/20 0.36
▸ PARG Q86W56 1/20 0.36
▸ PYCR1 P32322 1/20 0.35
▸ MEN1 O00255 3/20 0.35
▸ KMT2A Q03164 3/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ CYP2D6 P10635 1/20 0.35
▸ CYP2C9 P11712 1/20 0.35
▸ CYP2C19 P33261 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ S1PR3 Q99500 2/20 0.35
▸ CYP2A6 P11509 1/20 0.34
▸ TRPA1 O75762 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27567999 0.84 HTT (0.45) LMNAHTTTP53GABRA1GABRB1
SCHEMBL6742837 0.83 HTT (0.44) LMNAHTTTP53GABRA1GABRB1
SCHEMBL1345509 0.83 LMNA (0.64) LMNAHTTTP53MEN1KMT2A
SCHEMBL30917700 0.83 HTT (0.44) LMNAHTTTP53GABRA1GABRB1
SCHEMBL1345908 0.83 HTT (0.44) LMNAHTTTP53GABRA1GABRB1
SCHEMBL26239587 0.83 HTT (0.44) LMNAHTTTP53GABRA1GABRB1
SCHEMBL14268018 0.82 GABRA1 (0.46) LMNAHTTTP53GABRA1GABRB1
SCHEMBL31498780 0.82 GABRA1 (0.46) LMNAHTTTP53GABRA1GABRB1
SCHEMBL1569895 0.79 TP53 (0.39) LMNAHTTTP53PYCR1ALDH1A1
SCHEMBL12197660 0.78 GABRA1 (0.52) LMNAHTTTP53GABRA1GABRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-212375197-U 2-bromo-4-chlorine-1-isopropyl benzene production is with stewing device 上海雅本化学有限公司 2021-01-19 — — CN claimed
CN-111138242-A Synthesis method of 2-bromo-4-chloro-1-isopropylbenzene 上海雅本化学有限公司 2020-05-12 — — CN claimed
EP-2841413-B1 PROCESS FOR PREPARING N-(5-CHLORO-2-ISOPROPYLBENZYL)CYCLOPROPANAMINE BAYER CROPSCIENCE AG (DE) 2017-07-26 — — EP claimed
US-9440908-B2 Process for preparing N-(5-chloro-2-isopropylbenzyl)cyclopropanamine BAYER CROPSCIENCE AG (DE) 2016-09-13 — — US claimed
US-20150094492-A1 PROCESS FOR PREPARING N-(5-CHLORO-2-ISOPROPYLBENZYL)CYCLOPROPANAMINE BAYER CROPSCIENCE AG (DE) 2015-04-02 — — US claimed
EP-2841413-A1 PROCESS FOR PREPARING N-(5-CHLORO-2-ISOPROPYLBENZYL)CYCLOPROPANAMINE Bayer Cropscience AG (DE) 2015-03-04 — — EP claimed
WO-2013160387-A1 PROCESS FOR PREPARING N-(5-CHLORO-2-ISOPROPYLBENZYL)CYCLOPROPANAMINE BAYER CROPSCIENCE AG (DE) 2013-10-31 — — WO claimed
US-20230312522-A1 CYP46A1 INHIBITORS AND METHODS OF USE THEREOF SAGE THERAPEUTICS, INC. 2023-10-05 — — US disclosed
US-20230143470-A1 SMALL MOLECULE INHIBITORS OF INFLUENZA HEMAGGLUTININ NATIONAL INSTITUTES OF HEALTH 2023-05-11 — — US disclosed
CN-212375197-U 2-bromo-4-chlorine-1-isopropyl benzene production is with stewing device 上海雅本化学有限公司 2021-01-19 — — CN disclosed
CN-212375197-U 2-bromo-4-chlorine-1-isopropyl benzene production is with stewing device 上海雅本化学有限公司 2021-01-19 — — CN disclosed
CN-212375197-U 2-bromo-4-chlorine-1-isopropyl benzene production is with stewing device 上海雅本化学有限公司 2021-01-19 — — CN disclosed
CN-111138242-A Synthesis method of 2-bromo-4-chloro-1-isopropylbenzene 上海雅本化学有限公司 2020-05-12 — — CN disclosed
US-20150094492-A1 PROCESS FOR PREPARING N-(5-CHLORO-2-ISOPROPYLBENZYL)CYCLOPROPANAMINE BAYER CROPSCIENCE AG (DE) 2015-04-02 — — US disclosed
EP-2841413-A1 PROCESS FOR PREPARING N-(5-CHLORO-2-ISOPROPYLBENZYL)CYCLOPROPANAMINE Bayer Cropscience AG (DE) 2015-03-04 — — EP disclosed
US-20140235629-A1 HETEROCYCLIC COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER AMGEN INC. 2014-08-21 — — US disclosed
WO-2013160387-A1 PROCESS FOR PREPARING N-(5-CHLORO-2-ISOPROPYLBENZYL)CYCLOPROPANAMINE BAYER CROPSCIENCE AG (DE) 2013-10-31 — — WO disclosed
WO-2013160387-A1 PROCESS FOR PREPARING N-(5-CHLORO-2-ISOPROPYLBENZYL)CYCLOPROPANAMINE BAYER CROPSCIENCE AG (DE) 2013-10-31 — — WO disclosed
WO-2013049250-A1 HETEROCYCLIC COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER AMGEN INC. (US) 2013-04-04 — — WO disclosed
US-20120157306-A1 Substituted Fused Pyrimidinones and Dihydropyrimidinones BAYER CROPSCIENCE AG (DE) 2012-06-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230312522-A1 CYP46A1 INHIBITORS AND METHODS OF USE THEREOF CYP46A1, CYP26A1, CYP4A22 LMNA 2941/4885HTT 312/4885TP53 2663/4885
US-20140235629-A1 HETEROCYCLIC COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER MDM2, TP53, CDKN1A LMNA 3560/4885HTT 296/4885TP53 2/4885
US-20120157306-A1 Substituted Fused Pyrimidinones and Dihydropyrimidinones DHPS, FDPS, DPYD LMNA 4551/4885HTT 2675/4885TP53 3053/4885
US-20230143470-A1 SMALL MOLECULE INHIBITORS OF INFLUENZA HEMAGGLUTININ HAVCR2, CD44, ENGASE LMNA 2333/4885HTT 1336/4885TP53 181/4885
US-20150094492-A1 PROCESS FOR PREPARING N-(5-CHLORO-2-ISOPROPYLBENZYL)CYCLOPROPANAMINE PNMT, NT5C, CPNE4 LMNA 2232/4885HTT 625/4885TP53 3455/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.