Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | DRD3 | P35462 | 4/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.34 |
| ▸ | KYAT3 | Q6YP21 | 1/20 | 0.34 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
| ▸ | PYGM | P11217 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423564 | 0.87 | KYAT1 (0.46) | KDM1AKYAT1KYAT3AADATMMP8 | |
| SCHEMBL23119152 | 0.81 | GAA (0.38) | KDM1AGAASCN9APYGLPYGM | |
| SCHEMBL7419284 | 0.81 | AADAT (0.40) | AADATGAASCN9APYGLPYGM | |
| SCHEMBL9974770 | 0.80 | LIPG (0.39) | SCN9APYGLPYGM | |
| SCHEMBL7420732 | 0.77 | KYAT1 (0.42) | KDM1AKYAT1KYAT3AADATGAA | |
| SCHEMBL6644445 | 0.76 | DRD2 (0.52) | DRD2DRD3HTR1DKDM1A | |
| SCHEMBL9886293 | 0.75 | KDM1A (0.38) | KDM1AKYAT1KYAT3AADATGAA | |
| SCHEMBL20533140 | 0.74 | DRD2 (0.41) | DRD2DRD3HTR1D | |
| SCHEMBL20533142 | 0.74 | DRD2 (0.41) | DRD2DRD3HTR1D | |
| SCHEMBL23119153 | 0.73 | NPY1R (0.45) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082853-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2012-06-21 | — | — | WO | disclosed |