Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.67 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.67 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.67 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.67 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 3/20 | 0.63 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.58 |
| ▸ | PLCD1 | P51178 | 1/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.54 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.54 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.54 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31654083 | 0.98 | PRSS1 (0.65) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL26754234 | 0.98 | PRSS1 (0.65) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL4968230 | 0.92 | F2 (0.73) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL19017236 | 0.92 | F2 (0.73) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL19751698 | 0.92 | F2 (0.73) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL15216220 | 0.92 | F2 (0.73) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL17039697 | 0.90 | F2 (0.71) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL20097878 | 0.89 | F2 (0.71) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL8131388 | 0.89 | FOLH1 (0.71) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL7902281 | 0.88 | F2 (0.69) | F2PRSS1PRSS2PRSS3TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594962-B1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | PROMEGA CORP (US) | 2014-08-27 | — | — | EP | claimed |
| US-RE42931-E1 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION (US) | 2011-11-15 | — | — | US | claimed |
| US-7238842-B2 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION (US) | 2007-07-03 | — | — | US | claimed |
| US-11028424-B2 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION (US) | 2021-06-08 | — | — | US | disclosed |
| US-10604745-B2 | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule | PROMEGA CORPORATION (US) | 2020-03-31 | — | — | US | disclosed |
| US-20190218592-A1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | PROMEGA CORPORATION | 2019-07-18 | — | — | US | disclosed |
| US-10240184-B2 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION (US) | 2019-03-26 | — | — | US | disclosed |
| US-20190085305-A1 | METHOD OF IMMOBILIZING A PROTEIN OR MOLECULE VIA A MUTANT DEHALOGENASE THAT IS BOUND TO AN IMMOBILIZED DEHALOGENASE SUBSTRATE AND LINKED DIRECTLY OR INDIRECTLY TO THE PROTEIN OR MOLECULE | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2019-03-21 | — | — | US | disclosed |
| US-10101332-B2 | Covalent tethering of functional groups to proteins and substrates therefor | PROMEGA CORPORATION (US) | 2018-10-16 | — | — | US | disclosed |
| EP-3179252-A1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | Promega Corporation (US) | 2017-06-14 | — | — | EP | disclosed |
| EP-2395078-B1 | Covalent tethering of functional groups to proteins | PROMEGA CORP (US) | 2017-05-10 | — | — | EP | disclosed |
| US-7238842-B2 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| EP-1782071-A2 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | PROMEGA CORPORATION (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006093529-A2 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | PROMEGA CORPORATION (US) | 2006-09-08 | — | — | WO | disclosed |
| US-20060024808-A1 | Covalent tethering of functional groups to proteins and substrates therefor | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2006-02-02 | — | — | US | disclosed |
| US-20050272114-A1 | Substrates for covalent tethering to proteins | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2005-12-08 | — | — | US | disclosed |
| EP-1594962-A2 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | PROMEGA CORPORATION (US) | 2005-11-16 | — | — | EP | disclosed |
| US-20040214258-A1 | Covalent tethering of functional groups to proteins | PROMEGA CORPORATION | 2004-10-28 | — | — | US | disclosed |
| WO-2004072232-A9 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | PROMEGA CORP (US) | 2004-10-14 | — | — | WO | disclosed |
| WO-2004072232-A2 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | PROMEGA CORPORATION (US) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272114-A1 | Substrates for covalent tethering to proteins | DDHD2, ABHD14B, AHCYL1 | F2 3915/4885PRSS1 709/4885PRSS2 994/4885 |
| US-20190085305-A1 | METHOD OF IMMOBILIZING A PROTEIN OR MOLECULE VIA A MUTANT DEHALOGENASE THAT IS BOUND TO AN IMMOBILIZED DEHALOGENASE SUBSTRATE AND LINKED DIRECTLY OR INDIRECTLY TO THE PROTEIN OR MOLECULE | HDHD5, DDT, DDAH1 | F2 2508/4885PRSS1 1284/4885PRSS2 868/4885 |
| US-20190218592-A1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS | GGT1, HDHD5, DNPH1 | F2 2907/4885PRSS1 1059/4885PRSS2 1308/4885 |
| US-10604745-B2 | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule | HDHD5, DDT, DDAH1 | F2 2508/4885PRSS1 1284/4885PRSS2 868/4885 |
| US-11028424-B2 | Covalent tethering of functional groups to proteins | GGT1, HDHD5, DNPH1 | F2 2907/4885PRSS1 1059/4885PRSS2 1308/4885 |
| US-10101332-B2 | Covalent tethering of functional groups to proteins and substrates therefor | WASF2, NOTUM, YIPF5 | F2 3125/4885PRSS1 624/4885PRSS2 1128/4885 |
| US-20060024808-A1 | Covalent tethering of functional groups to proteins and substrates therefor | WASF2, NOTUM, YIPF5 | F2 3125/4885PRSS1 624/4885PRSS2 1128/4885 |
| US-10240184-B2 | Covalent tethering of functional groups to proteins | GGT1, HDHD5, DNPH1 | F2 2907/4885PRSS1 1059/4885PRSS2 1308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.