Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9979773 | 0.86 | CYP3A4 (0.49) | LMNATP53CYP3A4SYKALDH1A1 | |
| SCHEMBL3290937 | 0.83 | ALDH1A1 (0.44) | LMNATP53CYP3A4SYKALDH1A1 | |
| SCHEMBL115421 | 0.83 | LMNA (0.40) | LMNATP53CYP3A4SYKKDM4E | |
| SCHEMBL20079989 | 0.77 | LMNA (0.49) | LMNATP53SYKKDM4ETRPM5 | |
| SCHEMBL13500589 | 0.74 | NPC1 (0.49) | LMNATP53SYKALDH1A1KDM4E | |
| SCHEMBL10160045 | 0.74 | HTR1B (0.40) | TRPM5 | |
| SCHEMBL13500632 | 0.73 | GAA (0.50) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL14011321 | 0.73 | TACR1 (0.52) | ALDH1A1KDM4ERAB9A | |
| SCHEMBL15762727 | 0.73 | ALDH1A1 (0.48) | LMNAROCK2CYP3A4ALOX15ALDH1A1 | |
| SCHEMBL27304325 | 0.72 | TRPM5 (0.38) | TRPM5CHRNA7CA2CA12CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8779191-B2 | Methods and compositions for preparing lisdexamfetamine and salts thereof | CAMBREX CHARLES CITY, INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20120190880-A1 | METHODS AND COMPOSITIONS FOR PREPARATION OF AMPHETAMINE CONJUGATES AND SALTS THEREOF | BLUE OWL CAPITAL CORPORATION, AS NEW AGENT | 2012-07-26 | — | — | US | disclosed |
| US-20120157706-A1 | Methods and Compositions for Preparing Lisdexamfetamine and Salts Thereof | AVISTA PHARMA SOLUTIONS, INC. | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190880-A1 | METHODS AND COMPOSITIONS FOR PREPARATION OF AMPHETAMINE CONJUGATES AND SALTS THEREOF | PNMT, COMT, DDT | LMNA 2216/4885TP53 2963/4885ROCK2 2174/4885 |
| US-20120157706-A1 | Methods and Compositions for Preparing Lisdexamfetamine and Salts Thereof | SLC6A3, COMT, LPXN | LMNA 2265/4885TP53 4424/4885ROCK2 1404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.