SCHEMBL9978249

SCHEMBL9978249

O=[N+]([O-])c1cc(S(=O)(=O)Cl)ccc1OC(F)(F)F

nearest known ligand 0.49

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 1/20 0.49
EPAS1 Q99814 1/20 0.46
VCAM1 P19320 5/20 0.41
ALDH3A1 P30838 1/20 0.41
ALDH1A1 P00352 3/20 0.39
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA9 Q16790 1/20 0.37
POLB P06746 1/20 0.37
ATM Q13315 1/20 0.36
AGTR1 P30556 1/20 0.36
LMNA P02545 1/20 0.36
MASP2 O00187 1/20 0.36
F2 P00734 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6112739 0.85 CA2 (0.55) PTPN1EPAS1VCAM1ALDH1A1CA12
SCHEMBL17374554 0.81 PTPN1 (0.46) PTPN1EPAS1VCAM1ALDH3A1ALDH1A1
SCHEMBL12067872 0.81 VCAM1 (0.57) PTPN1EPAS1VCAM1ALDH3A1ALDH1A1
SCHEMBL1274774 0.80 PDE7A (0.54) EPAS1VCAM1ALDH1A1POLBLMNA
SCHEMBL4897543 0.80 ALDH1A1 (0.58) ALDH1A1POLBAGTR1
SCHEMBL2635603 0.78 S100A9 (0.53) EPAS1
SCHEMBL397137 0.78 HSPB1 (0.56) ALDH1A1POLBLMNA
SCHEMBL30062398 0.78 HSPB1 (0.56) ALDH1A1POLBLMNA
SCHEMBL1275605 0.78 HSPB1 (0.51) PTPN1EPAS1ATMLMNA
SCHEMBL7534887 0.77 VCAM1 (0.43) PTPN1EPAS1VCAM1ALDH1A1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4565323-A1 AROMATIC COMPOUNDS FOR USE AS PROTEIN PHOSPHATASE 2A (PP2A) MODULATORS Rappta Therapeutics Oy (FI) 2025-06-11 EP disclosed
CN-119968358-A Protein phosphatase 2A (PP 2A) modulators and methods of use thereof 拉普他治疗公司 2025-05-09 CN disclosed
US-20240174603-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME RAPPTA THERAPEUTICS OY (FI) 2024-05-30 US disclosed
US-20240174611-A1 SUBSTITUTED CYCLIC MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME RAPPTA THERAPEUTICS OY (FI) 2024-05-30 US disclosed
WO-2024028808-A1 AROMATIC COMPOUNDS FOR USE AS PROTEIN PHOSPHATASE 2A (PP2A) MODULATORS RAPPTA THERAPEUTICS OY (FI) 2024-02-08 WO disclosed
EP-4288414-A1 SUBSTITUTED CYCLIC MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME Rappta Therapeutics Oy (FI) 2023-12-13 EP disclosed
EP-4288412-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME Rappta Therapeutics Oy (FI) 2023-12-13 EP disclosed
CN-116806217-A Substituted cyclic modulators of protein phosphatase 2A (PP 2A) and methods of use thereof 拉帕塔疗法公司 2023-09-26 CN disclosed
WO-2022167867-A1 SUBSTITUTED CYCLIC MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME RAPPTA THERAPEUTICS OY (FI) 2022-08-11 WO disclosed
WO-2022167866-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME RAPPTA THERAPEUTICS OY (FI) 2022-08-11 WO disclosed
WO-2011149827-A1 COMPOUNDS AND METHODS GLAXOSMITHKLINE LLC (US) 2011-12-01 WO disclosed
WO-2011149827-A1 COMPOUNDS AND METHODS GLAXOSMITHKLINE LLC (US) 2011-12-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240174603-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME PPM1A, PPP2CA, PPP3CA PTPN1 57/4885EPAS1 813/4885VCAM1 2526/4885
US-20240174611-A1 SUBSTITUTED CYCLIC MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME PPP2CA, PPP3CA, PPP4C PTPN1 61/4885EPAS1 998/4885VCAM1 2558/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.