SCHEMBL998315

SCHEMBL998315

O=C(Cl)Oc1cc(OC(=O)Cl)cc(OC(=O)Cl)c1

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39
KDM4E B2RXH2 1/20 0.34
LMNA P02545 1/20 0.34
TTR P02766 1/20 0.34
TP53 P04637 1/20 0.34
CYP3A4 P08684 1/20 0.34
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
INPPL1 O15357 1/20 0.33
INPP5A Q14642 1/20 0.33
CYP19A1 P11511 1/20 0.31
ALDH1A1 P00352 1/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11705271 0.89 CYP3A4 (0.38) KMT2AMEN1CYP3A4MAPTALDH1A1
SCHEMBL11699992 0.87 MEN1 (0.32) KMT2AMEN1ALDH1A1TSHR
SCHEMBL17237455 0.87 KMT2A (0.37) KMT2AMEN1MAPT
SCHEMBL5025919 0.85 TPMT (0.44) KMT2AMEN1KDM4ELMNATTR
SCHEMBL11703365 0.84 MEN1 (0.41) KMT2AMEN1LMNACYP3A4MAPT
SCHEMBL2489203 0.84 KMT2A (0.60) KMT2AMEN1LMNACYP3A4
SCHEMBL890486 0.82 POLB (0.31) ALDH1A1TSHR
SCHEMBL3833597 0.82 ALDH1A1 (0.48) KMT2AMEN1LMNACYP3A4MAPT
SCHEMBL2928544 0.82 S1PR2 (0.45) KMT2AMEN1KDM4ELMNAMAPT
SCHEMBL4803849 0.82 CYP4F2 (0.44) TP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1556417-B1 RACEMOSELECTIVE PREPARATION OF BRIDGED METALLOCENE COMPLEXES HAVING UNSUBSTITUTED OR 2-SUBSTITUTED INDENYL LIGANDS BASELL POLYOLEFINE GMBH (DE) 2009-06-10 EP claimed
EP-1554297-B1 RACEMOSELECTIVE SYNTHESIS OF RAC-DIORGANOSILYLBIS(2-METHYLBENZO¬E|INDEYL) ZIRCONIUM COMPONDS BASELL POLYOLEFINE GMBH (DE) 2006-07-12 EP claimed
EP-0773481-B1 Photoconductive element containing polycarbonates crosslinked by aryltricarboxylic acids or their acid chlorides OCE TECH BV (NL) 2000-09-06 EP claimed
EP-0336999-B1 Reactive posttreatment for gas separation membranes AIR LIQUIDE (FR) 1995-09-06 EP claimed
EP-0275293-B1 POLYESTERS BIOCOMPATIBLES LTD. (GB) 1992-10-21 EP claimed
EP-0229470-B1 BRANCHED COPOLYETHERKETONES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-01-30 EP claimed
EP-0172934-A1 Microencapsulated naturally occuring pyrethrins PENNWALT CORPORATION (US) 1986-03-05 EP claimed
US-4497793-A Microencapsulated naturally occuring pyrethrins PENNWALT CORPORATION (US) 1985-02-05 US claimed
EP-3354710-B1 COMPOUNDS AND LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2020-12-23 EP disclosed
US-10711131-B2 High-strength rubber composition comprising an aromatic polyphenol derivative COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2020-07-14 US disclosed
EP-3354709-B1 COMPOUNDS AND LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2019-09-25 EP disclosed
US-20190177532-A1 HIGH-STRENGTH RUBBER COMPOSITION COMPRISING AN AROMATIC POLYPHENOL DERIVATIVE COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2019-06-13 US disclosed
EP-3354709-A1 COMPOUNDS AND LIQUID CRYSTALLINE MEDIUM Merck Patent GmbH (DE) 2018-08-01 EP disclosed
EP-3354710-A1 COMPOUNDS AND LIQUID CRYSTALLINE MEDIUM Merck Patent GmbH (DE) 2018-08-01 EP disclosed
EP-0292786-B1 STABILISED NEOPENTYLGLYCOL POLYCARBONATE BAYER AG (DE) 1992-08-26 EP disclosed
EP-0292786-A2 Stabilised neopentylglycol polycarbonate BAYER AG (DE) 1988-11-30 EP disclosed
EP-0172934-A1 Microencapsulated naturally occuring pyrethrins PENNWALT CORPORATION (US) 1986-03-05 EP disclosed
US-4497793-A Microencapsulated naturally occuring pyrethrins PENNWALT CORPORATION (US) 1985-02-05 US disclosed
US-4070434-A Method of manufacturing hollow plastic ball NIHON NODALON CO., LTD. (JA) 1978-01-24 US disclosed
US-4059565-A Process for producing a branched polycarbonate or poly(ester-carbonate) MITSUBISHI GAS CHEMICAL COMPANY, INC. (JA) 1977-11-22 US disclosed