Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 3/20 | 0.44 |
| ▸ | CCND1 | P24385 | 3/20 | 0.44 |
| ▸ | CDC7 | O00311 | 7/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9994932 | 0.95 | ALDH1A1 (0.46) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL15577123 | 0.88 | P2RX7 (0.56) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL16824128 | 0.87 | P2RX7 (0.55) | P2RX7CDK4CCND1CDC7PRMT5 | |
| SCHEMBL6995817 | 0.84 | ALDH1A1 (0.49) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL8430655 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL8255718 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL8430662 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL6990971 | 0.80 | HTR2A (0.50) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL6995071 | 0.79 | HTR2A (0.49) | ALDH1A1KDM4ETSHRHSD17B10HPGD | |
| SCHEMBL9995332 | 0.78 | KMO (0.59) | CDK4CCND1PRMT5MCL1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106420754-B | The purposes of benzo five-membered Azacyclyl bridged piperazine derivatives | 沈阳海王生物技术有限公司 | 2019-11-05 | — | — | CN | disclosed |
| US-9415047-B2 | Use of benzo five-membered nitrogen heterocyclic piperazine or piperidine derivatives | Liaoning Emmy Biological Pharmaceutical Co., Ltd. (CN) | 2016-08-16 | — | — | US | disclosed |
| US-20150297586-A1 | USE OF BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERAZINE OR PIPERIDINE DERIVATIVES | Liaoning Emmy Biological Pharmaceutical Co., Ltd. (CN) | 2015-10-22 | — | — | US | disclosed |
| EP-2924033-A1 | USE OF BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERAZINE OR PIPERIDINE DERIVATIVES | Liaoning Emmy Biological Pharmaceutical Co., Ltd (CN) | 2015-09-30 | — | — | EP | disclosed |
| US-20110306638-A1 | BENZISOXAZOLE PIPERIDINYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE DERIVATIVES AND THEIR USE | NHWA PHARMA. CORPORATION (CN) | 2011-12-15 | — | — | US | disclosed |
| CN-101759693-B | Benzo-isoxazol piperidine derivative and application in preparing analgesic and sedative medicaments | JIANGSU ENHUA PHARMACEUTICAL CO LTD | 2011-09-14 | — | — | CN | disclosed |
| CN-101759693-A | Benzo-isoxazol piperidine derivative and application in preparing analgesic and sedative medicaments | NHWA PHARMACEUTICAL GROUP CO L | 2010-06-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306638-A1 | BENZISOXAZOLE PIPERIDINYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE DERIVATIVES AND THEIR USE | HTR2A, HTR2C, HTR5A | ALDH1A1 442/4885KDM4E 1382/4885TSHR 636/4885 |
| US-20150297586-A1 | USE OF BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERAZINE OR PIPERIDINE DERIVATIVES | P2RX5, TBXA2R, CYP3A5 | ALDH1A1 372/4885KDM4E 931/4885TSHR 2743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.