Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | ACLY | P53396 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.49 |
| ▸ | CDK4 | P11802 | 3/20 | 0.49 |
| ▸ | CCND1 | P24385 | 3/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430623 | 0.83 | KMO (0.59) | KMOHTR7ACLYMCL1CDK4 | |
| SCHEMBL9994959 | 0.82 | P2RX7 (0.53) | KMOHTR7MCL1CDK4CCND1 | |
| SCHEMBL13668162 | 0.80 | KMO (0.56) | KMOHTR7ACLYMCL1CDK4 | |
| SCHEMBL8430621 | 0.79 | KMO (0.62) | KMOHTR7ACLYMCL1CDK4 | |
| SCHEMBL9995116 | 0.78 | ALDH1A1 (0.45) | KMOHTR7MCL1CDK4CCND1 | |
| SCHEMBL5661674 | 0.77 | CDK4 (0.81) | CDK4CCND1 | |
| SCHEMBL6549435 | 0.77 | ACLY (0.55) | KMOHTR7ACLYMCL1CDK4 | |
| SCHEMBL5635097 | 0.77 | HTR2C (0.53) | KMOHTR7MCL1CDK4CCND1 | |
| SCHEMBL12857017 | 0.77 | CDK4 (0.44) | KMOMCL1CDK4CCND1HDAC6 | |
| SCHEMBL1121929 | 0.76 | HTR7 (0.55) | KMOHTR7MCL1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306638-A1 | BENZISOXAZOLE PIPERIDINYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE DERIVATIVES AND THEIR USE | NHWA PHARMA. CORPORATION (CN) | 2011-12-15 | — | — | US | disclosed |
| CN-101759693-B | Benzo-isoxazol piperidine derivative and application in preparing analgesic and sedative medicaments | JIANGSU ENHUA PHARMACEUTICAL CO LTD | 2011-09-14 | — | — | CN | disclosed |
| CN-101759693-A | Benzo-isoxazol piperidine derivative and application in preparing analgesic and sedative medicaments | NHWA PHARMACEUTICAL GROUP CO L | 2010-06-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306638-A1 | BENZISOXAZOLE PIPERIDINYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE DERIVATIVES AND THEIR USE | HTR2A, HTR2C, HTR5A | KMO 620/4885HTR7 9/4885ACLY 2150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.