Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 7/20 | 0.56 |
| ▸ | HTR2A | P28223 | 6/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9995246 | 0.86 | DRD2 (0.58) | ACHEDRD2HTR2ASLC6A4HTR1A | |
| SCHEMBL15748188 | 0.85 | ACHE (0.56) | ACHEDRD2HTR2ASLC6A4HTR1A | |
| SCHEMBL9995298 | 0.84 | ACHE (0.62) | ACHEDRD2HTR2ASLC6A4HTR6 | |
| SCHEMBL9995251 | 0.84 | DRD2 (0.58) | ACHEDRD2HTR2ASLC6A4HTR1A | |
| SCHEMBL9995240 | 0.82 | ACHE (0.56) | ACHEDRD2HTR2ASLC6A4HTR1A | |
| SCHEMBL9995258 | 0.81 | HTR6 (0.57) | ACHEDRD2HTR2AHTR1AHRH3 | |
| SCHEMBL9994989 | 0.79 | ACHE (0.55) | ACHEDRD2HTR2ASLC6A4HTR1A | |
| SCHEMBL1836420 | 0.78 | ACHE (0.75) | ACHEDRD2HTR2ASLC6A4HTR1A | |
| SCHEMBL3122834 | 0.77 | ACHE (0.77) | ACHEDRD2HTR2ASLC6A4HTR1A | |
| SCHEMBL1545154 | 0.77 | HTR1A (0.73) | ACHEDRD2HTR2ASLC6A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306638-A1 | BENZISOXAZOLE PIPERIDINYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE DERIVATIVES AND THEIR USE | NHWA PHARMA. CORPORATION (CN) | 2011-12-15 | — | — | US | claimed |
| US-9415047-B2 | Use of benzo five-membered nitrogen heterocyclic piperazine or piperidine derivatives | Liaoning Emmy Biological Pharmaceutical Co., Ltd. (CN) | 2016-08-16 | — | — | US | disclosed |
| US-20150297586-A1 | USE OF BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERAZINE OR PIPERIDINE DERIVATIVES | Liaoning Emmy Biological Pharmaceutical Co., Ltd. (CN) | 2015-10-22 | — | — | US | disclosed |
| EP-2924033-A1 | USE OF BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERAZINE OR PIPERIDINE DERIVATIVES | Liaoning Emmy Biological Pharmaceutical Co., Ltd (CN) | 2015-09-30 | — | — | EP | disclosed |
| WO-2014079155-A1 | USE OF BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERAZINE OR PIPERIDINE DERIVATIVES | 辽宁贝雷生物制药有限公司 (CN) | 2014-05-30 | — | — | WO | disclosed |
| US-20110306638-A1 | BENZISOXAZOLE PIPERIDINYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE DERIVATIVES AND THEIR USE | NHWA PHARMA. CORPORATION (CN) | 2011-12-15 | — | — | US | disclosed |
| US-20110306638-A1 | BENZISOXAZOLE PIPERIDINYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE DERIVATIVES AND THEIR USE | NHWA PHARMA. CORPORATION (CN) | 2011-12-15 | — | — | US | disclosed |
| US-20110306638-A1 | BENZISOXAZOLE PIPERIDINYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE DERIVATIVES AND THEIR USE | NHWA PHARMA. CORPORATION (CN) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306638-A1 | BENZISOXAZOLE PIPERIDINYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE DERIVATIVES AND THEIR USE | HTR2A, HTR2C, HTR5A | ACHE 285/4885DRD2 75/4885HTR2A 1/4885 |
| US-20150297586-A1 | USE OF BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERAZINE OR PIPERIDINE DERIVATIVES | P2RX5, TBXA2R, CYP3A5 | ACHE 1108/4885DRD2 445/4885HTR2A 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.