SCHEMBL430962

SCHEMBL430962

O=Cc1ccc(I)c(O)c1

nearest known ligand 0.64

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.64
PTGS2 P35354 1/20 0.64
RAB9A P51151 1/20 0.64
ALDH1A1 P00352 5/20 0.52
AOX1 Q06278 1/20 0.52
ALDH5A1 P51649 3/20 0.47
ABAT P80404 3/20 0.47
TRIM24 O15164 1/20 0.47
HPGD P15428 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
TRIM33 Q9UPN9 1/20 0.47
TTR P02766 2/20 0.42
ERN1 O75460 2/20 0.42
XDH P47989 1/20 0.41
ACE P12821 1/20 0.41
PTGS1 P23219 1/20 0.41
LCK P06239 1/20 0.39
EGFR P00533 1/20 0.38
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31260317 1.00 KDM4E (0.64) KDM4EPTGS2RAB9AALDH1A1AOX1
SCHEMBL151496 0.82 KDM4E (0.64) KDM4EPTGS2RAB9AALDH1A1AOX1
SCHEMBL6902242 0.78 ALDH1A1 (0.46) KDM4EPTGS2RAB9AALDH1A1AOX1
Protocatechualdehyde SCHEMBL36350 0.78 KDM4E (1.00) KDM4EPTGS2RAB9AALDH1A1AOX1
Protocatechualdehyde SCHEMBL29349539 0.78 KDM4E (1.00) KDM4EPTGS2RAB9AALDH1A1AOX1
Protocatechualdehyde SCHEMBL9512877 0.78 KDM4E (1.00) KDM4EPTGS2RAB9AALDH1A1AOX1
Protocatechualdehyde SCHEMBL28071658 0.77 KDM4E (0.86) KDM4EPTGS2RAB9AALDH1A1AOX1
Protocatechualdehyde SCHEMBL4072910 0.76 KDM4E (0.95) KDM4EPTGS2RAB9AALDH1A1AOX1
Protocatechualdehyde SCHEMBL27876787 0.76 KDM4E (0.95) KDM4EPTGS2RAB9AALDH1A1AOX1
Protocatechualdehyde SCHEMBL27748932 0.76 KDM4E (0.95) KDM4EPTGS2RAB9AALDH1A1AOX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 139 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100500648-C Synthesizing process of nitro iodo phenol cyanide UNIV ZHEJIANG TECHNOLOGY (CN) 2009-06-17 CN claimed
CN-100999484-A Synthesizing process of nitro iodo phenol cyanide UNIV ZHEJIANG TECHNOLOGY (CN) 2007-07-18 CN claimed
EP-0488860-B1 Method for the production of polyalkoxylated aromatic compounds RHONE POULENC CHIMIE (FR) 1995-10-11 EP claimed
EP-0423010-B1 METHOD FOR THE PRODUCTION OF ALKOXYBENZALDEHYDES RHONE-POULENC CHIMIE (FR) 1993-09-29 EP claimed
EP-4716685-A1 IMIDAZO[4,5-C]PYRIDINE COMPOUNDS FOR THE TREATMENT OF CANCER F. Hoffmann-La Roche AG (CH) 2026-04-01 EP disclosed
US-20260070906-A1 IMIDAZO[4,5-C]PYRIDINE COMPOUNDS FOR THE TREATMENT OF CANCER HOFFMANN-LA ROCHE INC. (US) 2026-03-12 US disclosed
EP-3891149-B1 RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF SUNSHINE LAKE PHARMA CO LTD (CN) 2026-01-28 EP disclosed
US-12503477-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors GENZYME CORPORATION 2025-12-23 US disclosed
US-12459941-B2 Tricyclic IRAK inhibitors RIGEL PHARMACEUTICALS, INC. (US) 2025-11-04 US disclosed
EP-3820465-B1 SOLAR CELL DYES FOR COPPER REDOX BASED DYE SENSITIZED SOLAR CELLS AND COMBINATIONS THEREOF AMBIENT PHOTONICS INC (US) 2025-09-17 EP disclosed
CN-120136703-A Compound, polymer, composition for film formation, pattern formation method, method for forming insulating film, and method for producing compound 三菱瓦斯化学株式会社 2025-06-13 CN disclosed
CN-120136704-A Compound, polymer, composition for film formation, pattern formation method, method for forming insulating film, and method for producing compound 三菱瓦斯化学株式会社 2025-06-13 CN disclosed
EP-1861392-A2 SUBSTITUTED OXINDOL DERIVATIVES, DRUGS CONTAINING SAID DERIVATIVES AND THE USE THEREOF Abbott GmbH & Co. KG (DE) 2007-12-05 EP disclosed
CN-100999484-A Synthesizing process of nitro iodo phenol cyanide UNIV ZHEJIANG TECHNOLOGY (CN) 2007-07-18 CN disclosed
WO-2007071638-A1 COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR N.V. ORGANON (NL) 2007-06-28 WO disclosed
US-20070149577-A1 Compounds with medicinal effects due to interaction with the glucocorticoid receptor N.V. ORGANON (NL) 2007-06-28 US disclosed
WO-2007063123-A1 SUBSTITUTED OXINDOL-DERIVATIVES, MEDICAMENTS CONTAINING SAID DERIVATIVES AND USE THEREOF ABBOTT GMBH & CO. KG (DE) 2007-06-07 WO disclosed
WO-2006100082-A2 SUBSTITUTED OXINDOL DERIVATIVES, DRUGS CONTAINING SAID DERIVATIVES AND THE USE THEREOF ABBOTT GMBH & CO. KG (DE) 2006-09-28 WO disclosed
WO-2006100082-A2 SUBSTITUTED OXINDOL DERIVATIVES, DRUGS CONTAINING SAID DERIVATIVES AND THE USE THEREOF ABBOTT GMBH & CO. KG (DE) 2006-09-28 WO disclosed
CN-1768050-A Benzopyran compounds for the treatment of inflammation PHARMACIA CORP (US) 2006-05-03 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070149577-A1 Compounds with medicinal effects due to interaction with the glucocorticoid receptor NR3C1, NR3C2, MC2R KDM4E 2478/4885PTGS2 2428/4885RAB9A 2582/4885
US-12459941-B2 Tricyclic IRAK inhibitors IRAK1, IRAK2, IRAK3 KDM4E 573/4885PTGS2 2737/4885RAB9A 3079/4885
US-20260070906-A1 IMIDAZO[4,5-C]PYRIDINE COMPOUNDS FOR THE TREATMENT OF CANCER TLR1, TLR6, TLR8 KDM4E 1496/4885PTGS2 1342/4885RAB9A 1916/4885
US-12503477-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors CSF1R, CSF3R, IL1RN KDM4E 3985/4885PTGS2 1477/4885RAB9A 1201/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.