Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 6/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.52 |
| ▸ | HTR3B | O95264 | 5/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.52 |
| ▸ | HRH1 | P35367 | 5/20 | 0.49 |
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | HTR2B | P41595 | 3/20 | 0.49 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Noxiptiline SCHEMBL29358436 | 1.00 | HTR3A (0.52) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Noxiptiline SCHEMBL1649695 | 0.98 | HTR3A (0.51) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Noxiptiline SCHEMBL28221925 | 0.83 | SLC6A2 (0.63) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL11670230 | 0.79 | HTR3E (0.50) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9082805 | 0.79 | CES1 (0.38) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Hydrochloric Acid SCHEMBL11669953 | 0.78 | HTR3E (0.49) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL11755077 | 0.76 | HRH1 (0.53) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL11759087 | 0.73 | HRH1 (0.50) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL16474094 | 0.72 | PPARG (0.44) | ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL12143213 | 0.71 | LMNA (0.51) | ALDH1A1LMNAMAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1437 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240307386-A1 | NOVEL METHODS | INTRA-CELLULAR THERAPIES, INC. | 2024-09-19 | — | — | US | claimed |
| EP-4119536-B1 | PREPARATION OF A PHARMACEUTICAL INTERMEDIATE | DIPHARMA FRANCIS SRL (IT) | 2024-08-14 | — | — | EP | claimed |
| US-20230381168-A1 | ADJUNCTIVE THERAPY FOR DEPRESSION | ANEUROTECH BV (BE) | 2023-11-30 | — | — | US | claimed |
| US-20230053759-A1 | PREPARATION OF A PHARMACEUTICAL INTERMEDIATE | DIPHARMA FRANCIS S.R.L. (IT) | 2023-02-23 | — | — | US | claimed |
| EP-3801527-A1 | NOVEL METHODS | Intra-Cellular Therapies, Inc. (US) | 2021-04-14 | — | — | EP | claimed |
| US-20210060009-A1 | NOVEL METHODS | INTRA-CELLULAR THERAPIES, INC. | 2021-03-04 | — | — | US | claimed |
| EP-3765021-A1 | NOVEL METHODS | Intra-Cellular Therapies, Inc. (US) | 2021-01-20 | — | — | EP | claimed |
| US-20200390698-A1 | URETHRAL DEVICES FOR TREATMENT OF PATHOLOGICAL UROLOGICAL CONDITIONS | INURA MEDICAL AG (CH) | 2020-12-17 | — | — | US | claimed |
| US-20200038420-A1 | AMINOSTEROL COMPOSITIONS AND METHODS OF USING THE SAME FOR TREATING DEPRESSION | ENTERIN, INC. (US) | 2020-02-06 | — | — | US | claimed |
| WO-2019178484-A1 | NOVEL METHODS | INTRA-CELLULAR THERAPIES, INC. (US) | 2019-09-19 | — | — | WO | claimed |
| EP-1424068-A1 | Process for the preparation of pellets comprising a tricyclic or tetracyclic antidepressant and pharmaceutical compositions comprising these pellets | Oramon Arzneimittel GmbH (DE) | 2004-06-02 | — | — | EP | claimed |
| EP-1417165-A2 | DRUGS FOR CHRONIC PAINS | Nicox S.A. (FR) | 2004-05-12 | — | — | EP | claimed |
| US-20040076648-A1 | Topical compositions and methods for treating pain | EPICEPT CORPORATION | 2004-04-22 | — | — | US | claimed |
| US-20030082214-A1 | Topical compositions and methods for treating pain | DISCOVER GROWTH FUND, LLC (VI) | 2003-05-01 | — | — | US | claimed |
| WO-2003015699-A2 | TOPICAL COMPOSITIONS AND METHODS FOR TREATING PAIN | EPICEPT CORPORATION (US) | 2003-02-27 | — | — | WO | claimed |
| WO-2003000642-A2 | DRUGS FOR CHRONIC PAINS | NICOX S.A. (FR) | 2003-01-03 | — | — | WO | claimed |
| EP-1073470-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2001-02-07 | — | — | EP | claimed |
| WO-2000048636-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2000-08-24 | — | — | WO | claimed |
| EP-0775128-A1 | PREPARATION OF IMMUNOGENS AND OTHER CONJUGATES OF DRUGS | Dade Chemistry Systems Inc. (US) | 1997-05-28 | — | — | EP | claimed |
| WO-1996040664-A2 | PREPARATION OF IMMUNOGENS AND OTHER CONJUGATES OF DRUGS | DADE CHEMISTRY SYSTEMS INC. (US) | 1996-12-19 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210060009-A1 | NOVEL METHODS | HTR2A, HTR3B, HTR1A | HTR3A 8/4885HTR3E 14/4885HTR3B 2/4885 |
| US-20200038420-A1 | AMINOSTEROL COMPOSITIONS AND METHODS OF USING THE SAME FOR TREATING DEPRESSION | HSD17B7, CYP17A1, HSD17B2 | HTR3A 94/4885HTR3E 407/4885HTR3B 143/4885 |
| US-20240307386-A1 | NOVEL METHODS | OPRL1, HTR2A, OPRM1 | HTR3A 13/4885HTR3E 37/4885HTR3B 8/4885 |
| US-20230053759-A1 | PREPARATION OF A PHARMACEUTICAL INTERMEDIATE | PMP22, PYGB, COQ8A | HTR3A 1018/4885HTR3E 1192/4885HTR3B 719/4885 |
| US-20230381168-A1 | ADJUNCTIVE THERAPY FOR DEPRESSION | HTR2A, HTR3B, HTR5A | HTR3A 8/4885HTR3E 15/4885HTR3B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.