PLAAT4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL26657	0.53	10/20
SCHEMBL1027805	0.64	7/20
SCHEMBL1622156	0.50	6/20
SCHEMBL710419	0.62	5/20
SCHEMBL694045	0.58	4/20
SCHEMBL660787	0.56	4/20
SCHEMBL991969	0.56	4/20
SCHEMBL553140	0.50	4/20
SCHEMBL442914	0.46	4/20
SCHEMBL1645537	0.44	4/20
Phenethylcarbamic Acid (SCHEMBL249525)	0.63	3/20
SCHEMBL1567251	0.61	3/20
SCHEMBL159162	0.59	3/20
SCHEMBL426275	0.59	3/20
SCHEMBL1756655	0.59	3/20
SCHEMBL440625	0.57	3/20
SCHEMBL1776	0.56	3/20
SCHEMBL1681600	0.54	3/20
SCHEMBL659686	0.54	3/20
SCHEMBL349314	0.53	3/20

Clinical trials — most relevant to PLAAT4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Omega-3 Fatty Acids on the Human Gene Expression	PHASE4	COMPLETED
Cystagon to Treat Infantile Neuronal Ceroid Lipofuscinosis	PHASE4	COMPLETED
Hydroxychloroquine and Metabolic Outcomes in Patients Undergoing TPAIT	PHASE2	COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Insulin Regulation of Lipolysis and Lipolysis Proteins	EARLY_PHASE1	RECRUITING
Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes	nan	COMPLETED
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia	nan	UNKNOWN
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children	nan	WITHDRAWN
the Role of plin5 in the Development of Nonalcoholic Fatty Liver Disease.	nan	UNKNOWN
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
Genetical Background of Non-alcoholic Fatty Liver Disease (NAFLD) in Diabetes Mellitus and in Chronic Kidney Disease	nan	UNKNOWN
Choline to Improve Malnutrition and Enhance Cognition	nan	RECRUITING
Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies	nan	UNKNOWN
Genomic Dissection of a QTL Affecting the Lipid Profile	nan	WITHDRAWN
Epidemiology of Atherosclerosis	nan	COMPLETED
A 12 Week, 3-Period Study to Evaluate the Effects of a Dietary Supplement on Lipid Metabolism	nan	COMPLETED
Genetic and Environmental Determinants of Triglycerides (GOLDN)	nan	COMPLETED
Gene Expression in Obesity and Insulin Resistance	nan	COMPLETED
Genetic Markers of CHD Risk in Men and Women	nan	COMPLETED
Familial Partial Lipodystrophy Study	nan	COMPLETED
The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations	nan	COMPLETED
Thermogenic Silencer Regulatory Factors in Humans	nan	ACTIVE_NOT_RECRUITING
Lipa Gene Mutation in PED-LIPIGEN (Pediatric FH Subjects)	nan	UNKNOWN
Role of Dairy Products in Weight Maintenance	nan	COMPLETED
Serum FFA Desaturase Activity Index in Patients on High Dose Corticosteroids	nan	UNKNOWN
Identification of a New Gene Involved in Hereditary Lipodystrophy	nan	COMPLETED
Evaluation of Botanicals for Mechanisms Related to Appetite and Fat Metabolism	nan	COMPLETED
Plasma Free Fatty Acids Profile As A Diagnostic Tool For Acute Ischemic Stroke	nan	COMPLETED
Screening of Healthy Adults for Genetic Variations That Control Fatty Acid Processing	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PLAAT4 binder may also engage these)

Protein	Name	Similarity
Q9QZU4	—	0.984	Q9QZU4 →
Q9HDD0	—	0.983	Q9HDD0 →
A0A0R4IY06	—	0.981	A0A0R4IY06 →
D2KX21	—	0.979	D2KX21 →
Q9JI60	—	0.949	Q9JI60 →
Q93V51	—	0.946	Q93V51 →
O81209	—	0.945	O81209 →
O81211	—	0.944	O81211 →
Q9SW17	—	0.944	Q9SW17 →
Q9JI61	—	0.944	Q9JI61 →
Q01841	—	0.943	Q01841 →
O00534	—	0.943	O00534 →
O70370	—	0.942	O70370 →
P51176	—	0.942	P51176 →
Q99KC8	—	0.942	Q99KC8 →
Q92178	—	0.941	Q92178 →
Q3T9E4	—	0.941	Q3T9E4 →
Q9UIC8	—	0.941	Q9UIC8 →
Q91YH5	—	0.941	Q91YH5 →
Q9BSY9	—	0.941	Q9BSY9 →
Q8R3B1	—	0.941	Q8R3B1 →
Q91VA3	—	0.941	Q91VA3 →
Q9FM41	—	0.941	Q9FM41 →
Q7Z5M8	—	0.940	Q7Z5M8 →
Q5R8R3	—	0.940	Q5R8R3 →
Q4R802	—	0.940	Q4R802 →
Q9SUT8	—	0.940	Q9SUT8 →
Q62711	—	0.940	Q62711 →
Q9CQT7	—	0.940	Q9CQT7 →
P21981	—	0.940	P21981 →