SCHEMBL159162

SCHEMBL159162

O=C(S)NCCc1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.63
CA2 P00918 2/20 0.63
CA9 Q16790 2/20 0.63
EPHX1 P07099 1/20 0.61
PLAAT5 Q96KN8 3/20 0.59
PLAAT4 Q9UL19 3/20 0.59
MMP1 P03956 2/20 0.59
MMP2 P08253 2/20 0.59
CA1 P00915 1/20 0.59
MMP3 P08254 1/20 0.59
NPC1 O15118 4/20 0.59
RAB9A P51151 4/20 0.59
SMN1; SMN2 Q16637 3/20 0.59
ALDH1A1 P00352 2/20 0.58
TAAR1 Q96RJ0 1/20 0.58
HDAC2 Q92769 2/20 0.56
HDAC8 Q9BY41 2/20 0.56
HDAC6 Q9UBN7 2/20 0.56
PLAAT3 P53816 2/20 0.56
PLAAT2 Q9NWW9 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL156778 0.88 L3MBTL1 (0.68) EPHX1NPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL15550722 0.87 HDAC3 (0.68) CA12CA2CA9CA1TAAR1
SCHEMBL6032606 0.83 EPHX1 (0.85) CA12CA2CA9EPHX1PLAAT5
Phenethylcarbamic Acid SCHEMBL249525 0.83 CA12 (0.68) CA12CA2CA9EPHX1PLAAT5
SCHEMBL22412530 0.83 PLAAT5 (0.75) CA12CA2CA9EPHX1PLAAT5
SCHEMBL20144285 0.82 KDM4E (0.67) PLAAT5PLAAT4MMP1MMP2NPC1
SCHEMBL1567251 0.81 CA12 (0.66) CA12CA2CA9EPHX1PLAAT5
Phenethylcarbamic Acid SCHEMBL4459966 0.81 CA12 (0.66) CA12CA2CA9EPHX1PLAAT5
Phenethylcarbamic Acid SCHEMBL9718519 0.81 CA12 (0.66) CA12CA2CA9EPHX1PLAAT5
Phenethylcarbamic Acid SCHEMBL28010696 0.81 CA12 (0.66) CA12CA2CA9EPHX1PLAAT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1771162-B1 CAPSAICIN INHIBITORS FOR THE TREATMENT OF OBESITY-RELATED DISORDERS XENIA PHARMA (DK) 2013-06-05 EP claimed
US-8455504-B2 Inhibition of the activity of the capsaicin receptor in the treatment of type 1 diabetes, type 2 diabetes, impaired glucose tolerance or insulin resistance XENIA PHARMA (DK) 2013-06-04 US claimed
US-9918473-B2 Use of aryl carbamates in agriculture and other plant-related areas North Carolian State University (US) 2018-03-20 US disclosed
US-20160353739-A1 USE OF ARYL CARBAMATES IN AGRICULTURE AND OTHER PLANT-RELATED AREAS UNIV NORTH CAROLINA STATE (US) 2016-12-08 US disclosed
US-9439436-B2 Use of aryl carbamates in agriculture and other plant-related areas NORTH CAROLINA STATE UNIVERSITY (US) 2016-09-13 US disclosed
US-20150327552-A1 USE OF ARYL CARBAMATES IN AGRICULTURE AND OTHER PLANT-RELATED AREAS UNIV NORTH CAROLINA STATE (US) 2015-11-19 US disclosed
US-9125408-B2 Use of aryl carbamates in agriculture and other plant-related areas NORTH CAROLINA STATE UNIVERSITY (US) 2015-09-08 US disclosed
US-8884022-B2 Inhibition of bacterial biofilms with aryl carbamates NORTH CAROLINA STATE UNIVERSITY (US) 2014-11-11 US disclosed
US-20130172187-A1 USE OF ARYL CARBAMATES IN AGRICULTURE AND OTHER PLANT-RELATED AREAS NORTH CAROLINA STATE UNIVERSITY 2013-07-04 US disclosed
EP-1771162-B1 CAPSAICIN INHIBITORS FOR THE TREATMENT OF OBESITY-RELATED DISORDERS XENIA PHARMA (DK) 2013-06-05 EP disclosed
US-8455504-B2 Inhibition of the activity of the capsaicin receptor in the treatment of type 1 diabetes, type 2 diabetes, impaired glucose tolerance or insulin resistance XENIA PHARMA (DK) 2013-06-04 US disclosed
US-20060088786-A1 Rewritable optical information recording medium, recording and reproducing methods, as well as recording and reproducing apparatus MITSUI CHEMICALS, INC. (JP) 2006-04-27 US disclosed
WO-2006007851-A2 CAPSAICIN INHIBITORS FOR TREATING OBESITY AND-RELATED DISORDERS NOVO NORDISK A/S (DK) 2006-01-26 WO disclosed
EP-1311477-A4 NOVEL THIOCARBAMIC ACID DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME PACIFIC CORP (KR) 2005-01-12 EP disclosed
EP-1484191-A1 REWRITABLE OPTICAL INFORMATION RECORDING MEDIUM AND RECORDING/REPRODUCING METHOD, RECORDING/REPRODUCING DEVICE Sony Corporation (JP) 2004-12-08 EP disclosed
US-20030203944-A1 Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same PACIFIC CORPORATION (KR) 2003-10-30 US disclosed
EP-1311477-A1 NOVEL THIOCARBAMIC ACID DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME PACIFIC CORPORATION (KR) 2003-05-21 EP disclosed
WO-2002016317-A1 NOVEL THIOCARBAMIC ACID DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME PACIFIC CORPORATION (KR) 2002-02-28 WO disclosed
US-5637731-A CHOLINERGIC AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1997-06-10 US disclosed
US-5550257-A TREATING CENTRAL CHOLINERGIC DYSFUNCTION AMERICAN CYANAMID COMPANY (US) 1996-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130172187-A1 USE OF ARYL CARBAMATES IN AGRICULTURE AND OTHER PLANT-RELATED AREAS CTRC, ACE, DDT CA12 2660/4885CA2 342/4885CA9 623/4885
US-20160353739-A1 USE OF ARYL CARBAMATES IN AGRICULTURE AND OTHER PLANT-RELATED AREAS CTRC, ACE, DDT CA12 2660/4885CA2 342/4885CA9 623/4885
US-20060088786-A1 Rewritable optical information recording medium, recording and reproducing methods, as well as recording and reproducing apparatus ALPG, TRPC6, GNRHR CA12 665/4885CA2 660/4885CA9 492/4885
US-20150327552-A1 USE OF ARYL CARBAMATES IN AGRICULTURE AND OTHER PLANT-RELATED AREAS CTRC, ACE, DDT CA12 2660/4885CA2 342/4885CA9 623/4885
US-20030203944-A1 Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same TRPV1, TRPA1, TRPV5 CA12 711/4885CA2 364/4885CA9 289/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.