Ingliforib

Ingliforib

SCHEMBL122709

O=C(N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)N1C[C@@H](O)[C@@H](O)C1)c1cc2cc(Cl)ccc2[nH]1

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PYGL P06737 17/20 0.74
CYP51A1 Q16850 3/20 0.64
EGFR P00533 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ingliforib SCHEMBL7239034 1.00 PYGL (0.74) PYGLCYP51A1EGFR
Ingliforib SCHEMBL13483321 1.00 PYGL (0.74) PYGLCYP51A1EGFR
Ingliforib SCHEMBL8739351 1.00 PYGL (0.74) PYGLCYP51A1EGFR
Ingliforib SCHEMBL6705938 1.00 PYGL (0.74) PYGLCYP51A1EGFR
Ingliforib SCHEMBL29388624 1.00 PYGL (0.74) PYGLCYP51A1EGFR
SCHEMBL7244130 0.95 PYGL (0.74) PYGLCYP51A1EGFR
SCHEMBL13095871 0.94 PYGL (0.68) PYGLCYP51A1EGFR
SCHEMBL14140946 0.94 PYGL (0.68) PYGLCYP51A1EGFR
SCHEMBL15095241 0.94 PYGL (0.68) PYGLCYP51A1EGFR
SCHEMBL6742819 0.90 PYGL (0.78) PYGLCYP51A1EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260053761-A1 USE OF THYROMIMETICS FOR THE TREATMENT OF CANCER UNIV OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) 2026-02-26 US claimed
US-20230255974-A1 USE OF THYROMIMETICS FOR THE TREATMENT OF CANCER UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE 2023-08-17 US claimed
US-20110277339-A1 METHOD FOR MAKING HOMOGENEOUS SPRAY-DRIED SOLID AMORPHOUS DRUG DISPERSIONS UTILIZING MODIFIED SPRAY-DRYING APPARATUS LONZA BEND INC. 2011-11-17 US claimed
US-20110182947-A1 HYDROGEL-DRIVEN DRUG DOSAGE FORM BEND RESEARCH, INC. 2011-07-28 US claimed
EP-2275091-A1 Pharmaceutical compositions comprising adsorbates of an amorphous drug Pfizer Products Inc. (US) 2011-01-19 EP claimed
US-20030004162-A1 Use of glycogen phosphorylase inhibitors TREADWAY JUDITH L (US) 2003-01-02 US claimed
US-6297269-B1 Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors PFIZER INC. 2001-10-02 US claimed
EP-1136071-A2 Use of glycogen phosphorylase inhibitors Pfizer Products Inc. (US) 2001-09-26 EP claimed
US-20260053761-A1 USE OF THYROMIMETICS FOR THE TREATMENT OF CANCER UNIV OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) 2026-02-26 US disclosed
US-12186317-B2 Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase TES PHARMA S.R.L. (IT) 2025-01-07 US disclosed
US-20230381177-A1 INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE TES PHARMA S.R.L. (IT) 2023-11-30 US disclosed
US-20230255974-A1 USE OF THYROMIMETICS FOR THE TREATMENT OF CANCER UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE 2023-08-17 US disclosed
US-20220354848-A9 INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE TES PHARMA S.R.L. (IT) 2022-11-10 US disclosed
EP-3526199-B1 INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE TES PHARMA S R L (IT) 2022-04-13 EP disclosed
US-20040152758-A1 N-(indole-2-carbonyl)-b-alaninamide crystal forms PFIZER INC. 2004-08-05 US disclosed
US-6683106-B2 REDUCED SIDE EFFECTS; EFFICACY PFIZER INC. 2004-01-27 US disclosed
US-20030195243-A1 N-(indole-2-carbonyl)-b-alaninamide crystal forms PFIZER INC. 2003-10-16 US disclosed
US-20030004162-A1 Use of glycogen phosphorylase inhibitors TREADWAY JUDITH L (US) 2003-01-02 US disclosed
EP-1136071-A2 Use of glycogen phosphorylase inhibitors Pfizer Products Inc. (US) 2001-09-26 EP disclosed
WO-1996039385-A1 SUBSTITUTED N-(INDOLE-2-CARBONYL-) AMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS PFIZER INC. (US) 1996-12-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030195243-A1 N-(indole-2-carbonyl)-b-alaninamide crystal forms PYGL, PYGB, PYGM PYGL 1/4885CYP51A1 1806/4885EGFR 4056/4885
US-20220354848-A9 INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE ACMSD, GLS, ALDH7A1 PYGL 483/4885CYP51A1 832/4885EGFR 3729/4885
US-12186317-B2 Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase ACMSD, GLS, ALDH7A1 PYGL 483/4885CYP51A1 832/4885EGFR 3729/4885
US-20260053761-A1 USE OF THYROMIMETICS FOR THE TREATMENT OF CANCER THRA, THRB, TRHR PYGL 1869/4885CYP51A1 876/4885EGFR 1068/4885
US-20230381177-A1 INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE ACMSD, GLS, ALDH7A1 PYGL 483/4885CYP51A1 832/4885EGFR 3729/4885
US-20030004162-A1 Use of glycogen phosphorylase inhibitors PYGL, PYGM, GYS2 PYGL 1/4885CYP51A1 688/4885EGFR 4764/4885
US-20040152758-A1 N-(indole-2-carbonyl)-b-alaninamide crystal forms PYGL, PYGB, PYGM PYGL 1/4885CYP51A1 1806/4885EGFR 4056/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.