SCHEMBL674953

SCHEMBL674953

ONC(=S)Nc1ccccc1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.76
TAS2R38 P59533 3/20 0.76
HSD17B10 Q99714 2/20 0.76
CYP3A4 P08684 1/20 0.76
GAA P10253 7/20 0.70
KMT2A Q03164 5/20 0.70
MEN1 O00255 3/20 0.70
RAB9A P51151 2/20 0.70
NOX1 Q9Y5S8 2/20 0.70
NPC1 O15118 1/20 0.70
MAOA P21397 3/20 0.65
MAOB P27338 3/20 0.65
MAPT P10636 3/20 0.65
LMNA P02545 2/20 0.61
KDM4E B2RXH2 2/20 0.59
TP53 P04637 1/20 0.56
TYR P14679 1/20 0.56
TSHR P16473 1/20 0.56
SMN1; SMN2 Q16637 2/20 0.55
CYP1A2 P05177 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23324998 0.89 ALDH1A1 (0.68) ALDH1A1TAS2R38HSD17B10CYP3A4GAA
SCHEMBL132620 0.87 ALDH1A1 (1.00) ALDH1A1TAS2R38HSD17B10CYP3A4GAA
SCHEMBL9470190 0.84 ALDH1A1 (0.94) ALDH1A1TAS2R38HSD17B10CYP3A4GAA
SCHEMBL8956322 0.84 ALDH1A1 (0.94) ALDH1A1TAS2R38HSD17B10CYP3A4GAA
SCHEMBL730314 0.82 ALDH1A1 (0.80) ALDH1A1TAS2R38HSD17B10CYP3A4GAA
Thiourea SCHEMBL21055683 0.80 ALDH1A1 (0.85) ALDH1A1TAS2R38HSD17B10CYP3A4GAA
SCHEMBL5137359 0.79 ALDH1A1 (1.00) ALDH1A1TAS2R38HSD17B10CYP3A4GAA
SCHEMBL9243020 0.78 ALDH1A1 (0.81) ALDH1A1TAS2R38HSD17B10CYP3A4GAA
SCHEMBL23812525 0.78 GAA (0.84) ALDH1A1TAS2R38HSD17B10CYP3A4GAA
SCHEMBL13694679 0.78 ALDH1A1 (0.73) ALDH1A1TAS2R38HSD17B10CYP3A4GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250100980-A1 NOVEL LEUKOTRIENE B4 RECEPTOR INHIBITORS AND USE THEREOF EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION (KR) 2025-03-27 US claimed
WO-2023121022-A1 NOVEL LEUKOTRIENE B4 RECEPTOR INHIBITORS AND USE THEREOF 이화여자대학교 산학협력단 2023-06-29 WO claimed
CN-116180169-A Electronic plating additive composition and application thereof in inhibiting silver-ferrite interface nickel transverse electrodeposition 厦门大学 2023-05-30 CN claimed
US-20170100352-A1 Methods for treating or preventing neuroinflammation or autoimmune diseases ELFORD HOWARD L (US) 2017-04-13 US claimed
EP-2030615-A2 Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases ELFORD, Howard L. (US) 2009-03-04 EP claimed
US-20090047250-A1 Methods for treating or preventing neuroinflammation or autoimmune diseases ELFORD HOWARD L 2009-02-19 US claimed
US-20250100980-A1 NOVEL LEUKOTRIENE B4 RECEPTOR INHIBITORS AND USE THEREOF EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION (KR) 2025-03-27 US disclosed
US-20230293524-A1 OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY SPIRAL THERAPEUTICS INC. 2023-09-21 US disclosed
WO-2023121022-A1 NOVEL LEUKOTRIENE B4 RECEPTOR INHIBITORS AND USE THEREOF 이화여자대학교 산학협력단 2023-06-29 WO disclosed
CN-116180169-A Electronic plating additive composition and application thereof in inhibiting silver-ferrite interface nickel transverse electrodeposition 厦门大学 2023-05-30 CN disclosed
US-11234914-B2 Monosubstituted urea derivatives as a self-tanning substance MERCK PATENT GMBH (DE) 2022-02-01 US disclosed
US-20200038304-A1 MONOSUBSTITUTED UREA DERIVATIVES AS A SELF-TANNING SUBSTANCE MERCK PATENT GMBH (DE) 2020-02-06 US disclosed
US-20190142940-A1 Method and system for effecting changes in pigmented tissue MOAZED KAMBIZ THOMAS (US) 2019-05-16 US disclosed
CN-102070556-A 5-benzyl-4-alkyl-2-aminothiazole as well as preparation and application of 5-benzyl-4-alkyl-2-aminothiazole UNIV HUNAN 2011-05-25 CN disclosed
CN-102010406-A 4-(benzofuran-5-yl)-2-aromatic aminothiazole and preparation method and application thereof UNIV HUNAN 2011-04-13 CN disclosed
WO-2011011065-A1 METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE MOAZED KAMBIZ THOMAS (US) 2011-01-27 WO disclosed
WO-2010087983-A1 METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE MOAZED KAMBIZ THOMAS (US) 2010-08-05 WO disclosed
EP-2030615-A2 Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases ELFORD, Howard L. (US) 2009-03-04 EP disclosed
US-20090047250-A1 Methods for treating or preventing neuroinflammation or autoimmune diseases ELFORD HOWARD L 2009-02-19 US disclosed
CN-1337961-A Heteroaryl amidines, methyl amidiues and guanidines as protease inhibitors DIMENSIONAL PHARM INC (US) 2002-02-27 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250100980-A1 NOVEL LEUKOTRIENE B4 RECEPTOR INHIBITORS AND USE THEREOF LTB4R2, LTB4R, CYSLTR2 ALDH1A1 2694/4885TAS2R38 1165/4885HSD17B10 1482/4885
US-11234914-B2 Monosubstituted urea derivatives as a self-tanning substance SLC14A1, TYR, UROD ALDH1A1 422/4885TAS2R38 1259/4885HSD17B10 1598/4885
US-20090047250-A1 Methods for treating or preventing neuroinflammation or autoimmune diseases RNASE1, RNASEH1, TXNRD3 ALDH1A1 1031/4885TAS2R38 4058/4885HSD17B10 1470/4885
US-20170100352-A1 Methods for treating or preventing neuroinflammation or autoimmune diseases RNASE1, RNASEH1, TXNRD3 ALDH1A1 1031/4885TAS2R38 4058/4885HSD17B10 1470/4885
US-20200038304-A1 MONOSUBSTITUTED UREA DERIVATIVES AS A SELF-TANNING SUBSTANCE SLC14A1, TYR, UROD ALDH1A1 422/4885TAS2R38 1259/4885HSD17B10 1598/4885
US-20230293524-A1 OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY OTC, SLC26A4, OAT ALDH1A1 121/4885TAS2R38 795/4885HSD17B10 2300/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.