TOMM70 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL8288590	0.76	1/20
SCHEMBL7003055	0.74	1/20
SCHEMBL5451446	0.71	1/20
SCHEMBL5453282	0.71	1/20
SCHEMBL7002920	0.70	1/20
SCHEMBL5460515	0.69	1/20
SCHEMBL8289514	0.69	1/20
SCHEMBL13574989	0.69	1/20
SCHEMBL8288668	0.68	1/20
SCHEMBL8289505	0.68	1/20
SCHEMBL11324603	0.66	1/20
SCHEMBL26293177	0.64	1/20
SCHEMBL5449182	0.63	1/20
SCHEMBL26294993	0.63	1/20
SCHEMBL1067537	0.62	1/20
SCHEMBL8289822	0.62	1/20
SCHEMBL7003174	0.62	1/20
SCHEMBL8277600	0.62	1/20
SCHEMBL1066142	0.62	1/20
SCHEMBL23657531	0.62	1/20

Clinical trials — most relevant to TOMM70 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cardioprotective Effects of Melatonin in Patients With Cardiomyopathy	PHASE3	RECRUITING
ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma	PHASE2	COMPLETED
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis	PHASE2	UNKNOWN
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
Pioglitazone Therapy Targeting Fatigue in Breast Cancer	PHASE2	RECRUITING
Effectiveness of a Brain-Computer Interface Based System for Cognitive Enhancement in the Normal Elderly	PHASE1	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D)	EARLY_PHASE1	COMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
Low-Carbohydrate Normocaloric Diet in Patients With Head and Neck Carcinoma (HNC)	nan	COMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Polycystic Ovary Syndrome in Type 1 Diabetes	nan	NOT_YET_RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Pathogenic Insights and Search for Biomarkers in RFC1-ataxia/CANVAS	nan	RECRUITING
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise	nan	COMPLETED
Validation of the 18 kiloDalton Translocator Protein (TSPO) as a Novel Neuroimmunodulatory Target	nan	RECRUITING
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Inflammatory Status of Monocytes in Obesity	nan	UNKNOWN
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy	nan	RECRUITING
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Transcranial Photobiomodulation for the Treatment of Pediatric Depression	nan	WITHDRAWN
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TOMM70 binder may also engage these)

Protein	Name	Similarity
Q9CZW5	—	0.992	Q9CZW5 →
Q75Q39	—	0.991	Q75Q39 →
Q96RK4	—	0.969	Q96RK4 →
Q5ZIL9	—	0.966	Q5ZIL9 →
B5KFI0	—	0.959	B5KFI0 →
Q5F415	—	0.957	Q5F415 →
Q8C1Z7	—	0.957	Q8C1Z7 →
Q8VBV7	—	0.956	Q8VBV7 →
GPS1	COP9 signalosome complex subunit 1	0.955	landscape →
A2AWA9	—	0.955	A2AWA9 →
Q6P4Z9	—	0.953	Q6P4Z9 →
Q0P5I8	—	0.953	Q0P5I8 →
CDC16	Cell division cycle protein 16 homolog	0.953	landscape →
Q7L5D6	—	0.952	Q7L5D6 →
Q68FS2	—	0.952	Q68FS2 →
Q96JC1	—	0.952	Q96JC1 →
Q8R418	—	0.952	Q8R418 →
Q96AY4	—	0.951	Q96AY4 →
B4ZIX8	—	0.951	B4ZIX8 →
A0MQH0	—	0.951	A0MQH0 →
Q3T0V3	—	0.951	Q3T0V3 →
COPS8	COP9 signalosome complex subunit 8	0.951	landscape →
Q92624	—	0.951	Q92624 →
Q148V7	—	0.951	Q148V7 →
O88544	—	0.950	O88544 →
Q5R8I6	—	0.950	Q5R8I6 →
Q3SZA0	—	0.950	Q3SZA0 →
B1H1Z8	—	0.950	B1H1Z8 →
Q6PC62	—	0.950	Q6PC62 →
Q80XJ3	—	0.950	Q80XJ3 →