Sugi Predict

Sugi Predict / Compounds / SCHEMBL1000985

SCHEMBL1000985

SCHEMBL1000985

O=C(O)c1ccc2nc(Cl)ccc2c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CDH1 P12830 1/20 0.49
▸ APC P25054 1/20 0.49
▸ CTNNB1 P35222 1/20 0.49
▸ TCF7L2 Q9NQB0 1/20 0.49
▸ TDP1 Q9NUW8 3/20 0.49
▸ NAPRT Q6XQN6 1/20 0.48
▸ TSHR P16473 2/20 0.47
▸ KDM4E B2RXH2 7/20 0.45
▸ NPC1 O15118 5/20 0.45
▸ RAB9A P51151 5/20 0.45
▸ HPGD P15428 3/20 0.45
▸ SMN1; SMN2 Q16637 3/20 0.45
▸ GAA P10253 3/20 0.45
▸ ALDH1A1 P00352 2/20 0.45
▸ MEN1 O00255 2/20 0.45
▸ KMT2A Q03164 2/20 0.45
▸ TTR P02766 1/20 0.44
▸ ALB P02768 1/20 0.44
▸ MAOA P21397 1/20 0.44
▸ CNR1 P21554 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1680727 0.98 CDH1 (0.47) CDH1APCCTNNB1TCF7L2TDP1
Lithium SCHEMBL1680729 0.98 CDH1 (0.47) CDH1APCCTNNB1TCF7L2TDP1
Hydrochloric Acid SCHEMBL997515 0.98 CDH1 (0.47) CDH1APCCTNNB1TCF7L2TDP1
SCHEMBL2671556 0.87 TDP1 (0.50) CDH1APCCTNNB1TCF7L2TDP1
SCHEMBL29562439 0.87 TDP1 (0.50) CDH1APCCTNNB1TCF7L2TDP1
SCHEMBL997513 0.85 HPGD (0.41) CDH1APCCTNNB1TCF7L2NAPRT
SCHEMBL29371543 0.84 CYP2A6 (0.49) KDM4ENPC1RAB9AHPGDSMN1; SMN2
SCHEMBL3717520 0.84 CYP2A6 (0.49) KDM4ENPC1RAB9AHPGDSMN1; SMN2
Lithium Ion SCHEMBL1680728 0.82 HIPK2 (0.46) HPGD
SCHEMBL2671474 0.81 PLAU (0.55) TDP1KDM4ENPC1RAB9AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3856179-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-05-13 — — EP disclosed
EP-4494698-A2 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF Takeda Pharmaceutical Company Limited (JP) 2025-01-22 — — EP disclosed
EP-3661922-B1 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2024-10-23 — — EP disclosed
US-20240327410-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2024-10-03 — — US disclosed
CN-113164458-B Monoacylglycerol lipase modulators 詹森药业有限公司 2024-09-13 — — CN disclosed
US-20240254110-A1 FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1 CANCER RESEARCH TECH LTD (GB) 2024-08-01 — — US disclosed
US-20240199602-A1 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2024-06-20 — — US disclosed
US-11993601-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV 2024-05-28 — — US disclosed
US-11905285-B2 Inhibitors of plasma kallikrein and uses thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2024-02-20 — — US disclosed
US-11787786-B2 Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2023-10-17 — — US disclosed
CN-105308024-A Bicyclic nitrogen-containing aromatic heterocyclic amide compound ASTELLAS PHARMA INC 2016-02-03 — — CN disclosed
US-20150266869-A1 BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND ASTELLAS PHARMA INC. (JP) 2015-09-24 — — US disclosed
US-8822691-B2 Pesticidal carboxamides BAYER CROPSCIENCE AG (DE) 2014-09-02 — — US disclosed
US-20120277185-A1 Pesticidal Carboxamides BAYER CROPSCIENDE AG (DE) 2012-11-01 — — US disclosed
EP-2456759-A2 PESTICIDAL CARBOXAMIDES Bayer CropScience AG (DE) 2012-05-30 — — EP disclosed
US-20110195999-A1 NOVEL ANTIFUNGAL AGENT CONTAINING HETEROCYCLIC COMPOUND NAKAMOTO KAZUTAKA 2011-08-11 — — US disclosed
US-7932272-B2 Antifungal agent containing heterocyclic compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2011-04-26 — — US disclosed
WO-2011009540-A2 PESTICIDAL CARBOXAMIDES BAYER CROPSCIENCE AG (DE) 2011-01-27 — — WO disclosed
US-20070105943-A1 Novel antifungal agent containing heterocyclic compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2007-05-10 — — US disclosed
CN-1478078-A Nitrogen-containing aromatic ring derivatives ������������ʽ���� 2004-02-25 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120277185-A1 Pesticidal Carboxamides DDT, ACHE, AADAC CDH1 4076/4885APC 4836/4885CTNNB1 4226/4885
US-20240199602-A1 INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF KLKB1, KLK1, KLK5 CDH1 1809/4885APC 723/4885CTNNB1 2994/4885
US-20110195999-A1 NOVEL ANTIFUNGAL AGENT CONTAINING HETEROCYCLIC COMPOUND ERG28, CYP51A1, XPO1 CDH1 4807/4885APC 4795/4885CTNNB1 4356/4885
US-20070105943-A1 Novel antifungal agent containing heterocyclic compound ERG28, DPM1, CYP51A1 CDH1 4815/4885APC 4792/4885CTNNB1 4346/4885
US-11993601-B2 Monoacylglycerol lipase modulators MGLL, LPL, PNLIP CDH1 4525/4885APC 2542/4885CTNNB1 3964/4885
US-20240254110-A1 FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1 HSF1, HSP90AB1, HSPB1 CDH1 1934/4885APC 1030/4885CTNNB1 2001/4885
US-20150266869-A1 BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND PIK3CA, SLC16A3, MCTS1 CDH1 1745/4885APC 1022/4885CTNNB1 3745/4885
US-11787786-B2 Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1 HSF1, HSP90AB1, HSPB1 CDH1 1934/4885APC 1030/4885CTNNB1 2001/4885
US-11905285-B2 Inhibitors of plasma kallikrein and uses thereof KLKB1, KLK1, KLK5 CDH1 1809/4885APC 723/4885CTNNB1 2994/4885
US-20240327410-A1 Monoacylglycerol Lipase Modulators MGLL, LPL, PNLIP CDH1 4525/4885APC 2542/4885CTNNB1 3964/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.