Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.80 |
| ▸ | GAA | P10253 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12301165 | 0.74 | L3MBTL1 (0.57) | SMN1; SMN2MAPK1GAAALDH1A1KMT2A | |
| SCHEMBL6405540 | 0.73 | RXRA (0.71) | SMN1; SMN2ALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL17153776 | 0.70 | KDM4E (0.59) | SMN1; SMN2MAPK1GAAALDH1A1KMT2A | |
| SCHEMBL6404554 | 0.70 | TDP1 (0.70) | SMN1; SMN2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL1562702 | 0.69 | ALDH1A1 (0.76) | SMN1; SMN2MAPK1GAAALDH1A1KMT2A | |
| SCHEMBL20005776 | 0.68 | MAPT (0.55) | SMN1; SMN2GAAALDH1A1KMT2AMAPT | |
| SCHEMBL11381141 | 0.68 | MAPT (0.47) | SMN1; SMN2MAPK1GAAKMT2AMEN1 | |
| SCHEMBL6264206 | 0.68 | KDM4E (0.56) | SMN1; SMN2MAPK1GAAALDH1A1KMT2A | |
| SCHEMBL15062005 | 0.67 | LMNA (0.57) | GAAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL5824932 | 0.66 | KMT2A (0.52) | GAAALDH1A1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140255386-A1 | MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140255386-A1 | MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME | NORTH CAROLINA STATE UNIVERSITY (US) | 2014-09-11 | — | — | US | disclosed |
| WO-2013019469-A1 | MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME | THE WISTAR INSTITUTE (US) | 2013-02-07 | — | — | WO | disclosed |
| US-20130023498-A1 | MicroRNA Modulators and Method for Identifying and Using the Same | The Wistar Institute and North Carolina State University | 2013-01-24 | — | — | US | disclosed |
| US-20130023498-A1 | MicroRNA Modulators and Method for Identifying and Using the Same | The Wistar Institute and North Carolina State University | 2013-01-24 | — | — | US | disclosed |
| US-20120010177-A1 | MicroRNA Modulators and Method for Identifying And Using The Same | The Wistar Institute / North Carolina State University (US) | 2012-01-12 | — | — | US | disclosed |
| US-20120010177-A1 | MicroRNA Modulators and Method for Identifying And Using The Same | The Wistar Institute / North Carolina State University (US) | 2012-01-12 | — | — | US | disclosed |
| US-20100196357-A1 | Microrna modulators and method for identifying and using the same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-08-05 | — | — | US | disclosed |
| US-20100196357-A1 | Microrna modulators and method for identifying and using the same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100196357-A1 | Microrna modulators and method for identifying and using the same | AGO2, RNASE1, TRDMT1 | SMN1; SMN2 3647/4885MAPK1 2787/4885GAA 1241/4885 |
| US-20130023498-A1 | MicroRNA Modulators and Method for Identifying and Using the Same | AGO2, RNASE1, TRDMT1 | SMN1; SMN2 3647/4885MAPK1 2787/4885GAA 1241/4885 |
| US-20120010177-A1 | MicroRNA Modulators and Method for Identifying And Using The Same | AGO2, RNASE1, TRDMT1 | SMN1; SMN2 3647/4885MAPK1 2787/4885GAA 1241/4885 |
| US-20140255386-A1 | MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME | AGO2, RNASE1, TRDMT1 | SMN1; SMN2 3647/4885MAPK1 2787/4885GAA 1241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.