Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | TP53 | P04637 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729507 | 0.72 | TRPM8 (0.67) | MAPTTP53ALDH1A1THRBGAA | |
| SCHEMBL3966552 | 0.62 | PPARA (0.54) | MAPTALDH1A1 | |
| Fipexide SCHEMBL532910 | 0.62 | LMNA (1.00) | MAPTALDH1A1TSHRLMNAMAPK1 | |
| SCHEMBL20363079 | 0.61 | TRPM8 (0.63) | MAPTALDH1A1TSHRLMNAMAPK1 | |
| Fipexide SCHEMBL467102 | 0.61 | CYP3A4 (1.00) | MAPTALDH1A1TSHRLMNAMAPK1 | |
| SCHEMBL24827533 | 0.61 | HTT (0.52) | ALDH1A1TSHRMAPK1HTTPOLB | |
| SCHEMBL19002782 | 0.61 | HTT (0.51) | ALDH1A1TSHRLMNAMAPK1HTT | |
| SCHEMBL5137552 | 0.60 | ALDH1A1 (0.52) | MAPTALDH1A1TSHRLMNAMAPK1 | |
| SCHEMBL17233499 | 0.60 | TRPM8 (0.61) | TP53ALDH1A1POLB | |
| SCHEMBL17233487 | 0.60 | TRPM8 (0.61) | TP53ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163788-B2 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT BONN (DE) | 2012-04-24 | — | — | US | disclosed |
| US-8163788-B2 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT BONN (DE) | 2012-04-24 | — | — | US | disclosed |
| US-20100048594-A1 | USE OF CYTOHESIN INHIBITORS FOR CHEMICALLY INDUCING LONGEVITY | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT (DE) | 2010-02-25 | — | — | US | disclosed |
| US-20100048594-A1 | USE OF CYTOHESIN INHIBITORS FOR CHEMICALLY INDUCING LONGEVITY | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT (DE) | 2010-02-25 | — | — | US | disclosed |
| US-20090105286-A1 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT (DE) | 2009-04-23 | — | — | US | disclosed |
| US-20090105286-A1 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT (DE) | 2009-04-23 | — | — | US | disclosed |
| WO-2008058995-A2 | USE OF CYTOHESIN INHIBITORS FOR CHEMICALLY INDUCING LONGEVITY | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITÄT (DE) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048594-A1 | USE OF CYTOHESIN INHIBITORS FOR CHEMICALLY INDUCING LONGEVITY | IGFBP1, IGFBP2, IGFBP5 | MAPT 3756/4885TP53 288/4885ALDH1A1 2104/4885 |
| US-20090105286-A1 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | CYTH2, CYTH3, ENTPD5 | MAPT 4844/4885TP53 1898/4885ALDH1A1 4265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.