SCHEMBL1001815

SCHEMBL1001815

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nearest known ligand 0.50

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PDE4A P27815 1/20 0.50
USP2 O75604 1/20 0.47
SLCO1B1 Q9Y6L6 1/20 0.47
LMNA P02545 2/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
TDP1 Q9NUW8 1/20 0.41
OR51E2 Q9H255 1/20 0.33
KDM4E B2RXH2 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8465610 0.84 PDE4A (0.54) PDE4AUSP2SLCO1B1LMNAL3MBTL1
SCHEMBL6274785 0.82 PDE4A (0.52) PDE4AUSP2SLCO1B1LMNAL3MBTL1
SCHEMBL3708519 0.82 PDE4A (0.44) PDE4AUSP2SLCO1B1LMNAL3MBTL1
SCHEMBL3709949 0.82 PDE4A (0.44) PDE4AUSP2SLCO1B1LMNAL3MBTL1
SCHEMBL4395659 0.82 PDE4A (0.44) PDE4AUSP2SLCO1B1LMNAL3MBTL1
SCHEMBL1656749 0.81 PDE4A (0.50) PDE4AUSP2SLCO1B1LMNAL3MBTL1
SCHEMBL4393096 0.80 PDE4A (0.42) PDE4AUSP2SLCO1B1LMNAL3MBTL1
SCHEMBL4395512 0.79 PDE4A (0.59) PDE4AUSP2SLCO1B1LMNAL3MBTL1
SCHEMBL3289378 0.79 PDE4A (0.48) PDE4AUSP2SLCO1B1LMNAL3MBTL1
SCHEMBL1005420 0.79 PDE4A (0.59) PDE4AUSP2SLCO1B1LMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10612029-B2 Microorganisms and methods for the production of aniline GENOMATICA, INC. (US) 2020-04-07 US disclosed
US-20190328719-A1 METHODS OF TREATING DEVELOPMENTAL DISORDERS AND/OR SEIZURE DISORDERS WITH FLUPIRTINE OVID THERAPEUTICS INC. 2019-10-31 US disclosed
CN-110225754-A Method for treating developmental disorders and/or seizure disorders with flupirtine 奥维德医疗公司 2019-09-10 CN disclosed
EP-3528807-A1 METHODS OF TREATING DEVELOPMENTAL DISORDERS AND/OR SEIZURE DISORDERS WITH FLUPIRTINE Ovid Therapeutics Inc (US) 2019-08-28 EP disclosed
US-20190153454-A1 MICROORGANISMS FOR THE PRODUCTION OF ANILINE GENOMATICA, INC. 2019-05-23 US disclosed
US-20190105308-A1 METHODS OF TREATING DEVELOPMENTAL DISORDERS AND/OR SEIZURE DISORDERS WITH FLUPIRTINE OVID THERAPEUTICS INC (US) 2019-04-11 US disclosed
US-10167477-B2 Microorganisms and methods for the production of aniline GENOMATICA, INC. (US) 2019-01-01 US disclosed
US-20180195076-A1 MICROORGANISMS FOR THE PRODUCTION OF ANILINE GENOMATICA, INC. 2018-07-12 US disclosed
WO-2018098111-A1 METHODS OF TREATING DEVELOPMENTAL DISORDERS AND/OR SEIZURE DISORDERS WITH FLUPIRTINE OVID THERAPEUTICS INC. (US) 2018-05-31 WO disclosed
US-20180140586-A1 METHODS OF TREATING DEVELOPMENTAL DISORDERS AND/OR SEIZURE DISORDERS WITH FLUPIRTINE OVID THERAPEUTICS INC. 2018-05-24 US disclosed
US-20100120906-A1 MODIFIED RELEASE FORMULATION AND METHODS OF USE VALEANT PHARMACEUTICALS INTERNATIONAL (US) 2010-05-13 US disclosed
WO-2010008894-A1 BENZYLOXY ANILIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS VALEANT PHARMACEUTICALS INTERNATIONAL (US) 2010-01-21 WO disclosed
WO-2010009433-A1 MODIFIED RELEASE FORMULATION AND METHODS OF USE VALEANT PHARMACEUTICALS INTERNATIONAL (US) 2010-01-21 WO disclosed
US-20090326059-A1 BENZYLOXY ANILIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS VALEANT PHARMACEUTICALS INTERNATIONAL (US) 2009-12-31 US disclosed
EP-2086925-A1 1,4 DIAMINO BICYCLIC RETIGABINE ANALOGUES AS POTASSIUM CHANNEL MODULATORS Valeant Pharmaceuticals International (US) 2009-08-12 EP disclosed
EP-2061465-A2 DERIVATIVES OF 4-(N-AZACYCLOALKYL) ANILIDES AS POTASSIUM CHANNEL MODULATORS Valeant Pharmaceuticals International (US) 2009-05-27 EP disclosed
US-20080234334-A1 1,4 DIAMINO BICYCLIC RETIGABINE ANALOGUES AS POTASSIUM CHANNEL MODULATORS VALEANT PHARMACEUTICALS INTERNATIONAL (US) 2008-09-25 US disclosed
US-20080139610-A1 Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators VALEANT PHARMACEUTICALS NORTH AMERICA (US) 2008-06-12 US disclosed
WO-2008066900-A1 1,4 DIAMINO BICYCLIC RETIGABINE ANALOGUES AS POTASSIUM CHANNEL MODULATORS VALEANT PHARMACEUTICALS INTERNATIONAL (US) 2008-06-05 WO disclosed
WO-2008024398-A2 DERIVATIVES OF 4-(N-AZACYCLOALKYL) ANILIDES AS POTASSIUM CHANNEL MODULATORS VALEANT PHARMACEUTICALS INTERNATIONAL (US) 2008-02-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190328719-A1 METHODS OF TREATING DEVELOPMENTAL DISORDERS AND/OR SEIZURE DISORDERS WITH FLUPIRTINE GRIN2C, SYNGR2, GRIK5 PDE4A 420/4885USP2 3408/4885SLCO1B1 3757/4885
US-20080139610-A1 Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators KCNQ2, KCNQ1, KCNQ5 PDE4A 1603/4885USP2 3947/4885SLCO1B1 667/4885
US-20100120906-A1 MODIFIED RELEASE FORMULATION AND METHODS OF USE HNMT, HCN3, HRH4 PDE4A 786/4885USP2 1797/4885SLCO1B1 921/4885
US-20190105308-A1 METHODS OF TREATING DEVELOPMENTAL DISORDERS AND/OR SEIZURE DISORDERS WITH FLUPIRTINE GRIN2C, SYNGR2, GRIK5 PDE4A 420/4885USP2 3408/4885SLCO1B1 3757/4885
US-20080234334-A1 1,4 DIAMINO BICYCLIC RETIGABINE ANALOGUES AS POTASSIUM CHANNEL MODULATORS KCNB2, KCNB1, KCNA1 PDE4A 1030/4885USP2 4544/4885SLCO1B1 818/4885
US-20180140586-A1 METHODS OF TREATING DEVELOPMENTAL DISORDERS AND/OR SEIZURE DISORDERS WITH FLUPIRTINE GRIN2C, SYNGR2, GRIK5 PDE4A 420/4885USP2 3408/4885SLCO1B1 3757/4885
US-20090326059-A1 BENZYLOXY ANILIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS KCND2, KCNB2, KCNAB1 PDE4A 948/4885USP2 4248/4885SLCO1B1 1419/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.