Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL419320 | 0.79 | RAB9A (0.44) | RAB9ANPC1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL19569164 | 0.79 | NISCH (0.42) | RAB9AKDM4ESMN1; SMN2ALDH1A1NISCH | |
| SCHEMBL5219548 | 0.75 | DGAT1 (0.41) | RAB9ANPC1SMN1; SMN2TP53MAPK13 | |
| SCHEMBL1691510 | 0.74 | KDM4E (0.53) | RAB9ANPC1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL538459 | 0.74 | NPC1 (0.52) | RAB9ANPC1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL13258488 | 0.72 | LMNA (0.42) | KDM4EHPGDSMN1; SMN2TP53MAPK13 | |
| SCHEMBL11587705 | 0.71 | ALDH1A1 (0.50) | RAB9ANPC1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL10171975 | 0.70 | ALDH1A1 (0.51) | RAB9ANPC1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL2848588 | 0.69 | ALPL (0.66) | RAB9ANPC1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL22182004 | 0.68 | TNIK (0.39) | RAB9ANPC1SMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165322-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165322-A1 | RHO KINASE INHIBITORS | ROCK1, ROCK2, RHOA | RAB9A 100/4885NPC1 600/4885KDM4E 2031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.