Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.82 |
| ▸ | LMNA | P02545 | 4/20 | 0.82 |
| ▸ | HPGD | P15428 | 4/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | TOP2A | P11388 | 1/20 | 0.82 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.82 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | CASP9 | P55211 | 1/20 | 0.60 |
| ▸ | BAX | Q07812 | 1/20 | 0.60 |
| ▸ | BRD4 | O60885 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ciprofloxacin SCHEMBL10392202 | 0.92 | KDM4E (0.94) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL8983611 | 0.91 | KDM4E (0.78) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL22163788 | 0.91 | KDM4E (0.92) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL28201587 | 0.91 | KDM4E (0.96) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL29137332 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL2900 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL345730 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL2325956 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL4459712 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Ciprofloxacin SCHEMBL3134064 | 0.89 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746116-B2 | Antibiotic resistance breakers | KING'S COLLEGE LONDON (GB) | 2023-09-05 | — | — | US | disclosed |
| US-20180002297-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | MIDCAP FINANCIAL TRUST | 2018-01-04 | — | — | US | disclosed |
| US-20170204118-A1 | METAL ORGANIC FRAMEWORK WITH PERFLUORINATED LINKER | YOUNGSTOWN STATE UNIVERSITY (US) | 2017-07-20 | — | — | US | disclosed |
| US-9701647-B2 | Tetrazolones as a carboxylic acid bioisosteres | RIGEL PHARMACEUTICALS, INC. (US) | 2017-07-11 | — | — | US | disclosed |
| US-20170129862-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | MIDCAP FINANCIAL TRUST | 2017-05-11 | — | — | US | disclosed |
| US-9439888-B2 | Tetrazolones as a carboxylic acid bioisosteres | RIGEL PHARMACEUTICALS, INC. (US) | 2016-09-13 | — | — | US | disclosed |
| US-20160213648-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | MIDCAP FINANCIAL TRUST | 2016-07-28 | — | — | US | disclosed |
| US-8962786-B2 | Chain extenders | POLYNOVO BIOMATERIALS PTY LTD (AU) | 2015-02-24 | — | — | US | disclosed |
| US-20120046246-A1 | METHODS FOR TREATING OSTEOCLAST-RELATED DISEASE, COMPOUNDS AND COMPOSITIONS THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2012-02-23 | — | — | US | disclosed |
| US-20080287396-A1 | Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections | TARGANTA THERAPEUTICA INC. (CA) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170204118-A1 | METAL ORGANIC FRAMEWORK WITH PERFLUORINATED LINKER | AFF2, HNRNPF, SLC30A7 | KDM4E 4269/4885ALDH1A1 1417/4885LMNA 4264/4885 |
| US-20080287396-A1 | Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections | BPGM, PSPH, PGLS | KDM4E 3645/4885ALDH1A1 4175/4885LMNA 3228/4885 |
| US-20170129862-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | GLS, CYP11B2, GLS2 | KDM4E 4668/4885ALDH1A1 515/4885LMNA 2953/4885 |
| US-11746116-B2 | Antibiotic resistance breakers | ABCC1, ARL1, AKR1C3 | KDM4E 3599/4885ALDH1A1 481/4885LMNA 270/4885 |
| US-20160213648-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | GLS, CYP11B2, GLS2 | KDM4E 4668/4885ALDH1A1 515/4885LMNA 2953/4885 |
| US-20180002297-A1 | Tetrazolones as a Carboxylic Acid Bioisosteres | GLS, CYP11B2, GLS2 | KDM4E 4668/4885ALDH1A1 515/4885LMNA 2953/4885 |
| US-20120046246-A1 | METHODS FOR TREATING OSTEOCLAST-RELATED DISEASE, COMPOUNDS AND COMPOSITIONS THEREOF | CTSB, SOST, CTSG | KDM4E 1873/4885ALDH1A1 2363/4885LMNA 1220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.