Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.69 |
| ▸ | RAB9A | P51151 | 6/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.69 |
| ▸ | TP53 | P04637 | 4/20 | 0.69 |
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.69 |
| ▸ | RELA | Q04206 | 1/20 | 0.69 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.64 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | GUSB | P08236 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18650263 | 0.87 | NPC1 (0.89) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL11964433 | 0.83 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL3491706 | 0.82 | GSK3B (0.61) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL12974 | 0.81 | HPGD (0.73) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL9341650 | 0.80 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL11812106 | 0.79 | RAB9A (0.70) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL13393581 | 0.79 | TRPM8 (0.60) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL1186494 | 0.79 | GUSB (0.51) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL21776967 | 0.79 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL8118542 | 0.79 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119431269-A | Method for synthesizing 1,3, 4-oxadiazole compound from 1, 2-dihydrazide compound | 浙江工业大学 | 2025-02-14 | — | — | CN | disclosed |
| US-9505749-B2 | Quinazolinone compounds and derivatives thereof | AMGEN INC. (US) | 2016-11-29 | — | — | US | disclosed |
| US-20150225396-A1 | Quinazolinone Compounds and Derivatives Thereof | AMGEN INC. | 2015-08-13 | — | — | US | disclosed |
| WO-2014036022-A1 | QUINAZOLINONE COMPOUNDS AND DERIVATIVES THEREOF | AMGEN INC. (US) | 2014-03-06 | — | — | WO | disclosed |
| US-20120142676-A1 | Oxathiazine and dithiine oxides as inhibitors of sulfhydryl-dependent biomolecules | CHEE GAIK-LEAN (CA) | 2012-06-07 | — | — | US | disclosed |
| US-20120142676-A1 | Oxathiazine and dithiine oxides as inhibitors of sulfhydryl-dependent biomolecules | CHEE GAIK-LEAN (CA) | 2012-06-07 | — | — | US | disclosed |
| US-20100099672-A1 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099672-A1 | METHODS FOR TREATING HEPATITIS C | OAT, HAVCR2, HCCS | NPC1 291/4885RAB9A 3935/4885SMN1; SMN2 4442/4885 |
| US-20150225396-A1 | Quinazolinone Compounds and Derivatives Thereof | TNKS, TPI1, TNKS1BP1 | NPC1 3907/4885RAB9A 2806/4885SMN1; SMN2 3743/4885 |
| US-20120142676-A1 | Oxathiazine and dithiine oxides as inhibitors of sulfhydryl-dependent biomolecules | HPGDS, SHMT1, QSOX1 | NPC1 2313/4885RAB9A 4401/4885SMN1; SMN2 4655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.