Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.68 |
| ▸ | ACLY | P53396 | 10/20 | 0.43 |
| ▸ | MMP1 | P03956 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | MMP3 | P08254 | 3/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MMP8 | P22894 | 3/20 | 0.41 |
| ▸ | MMP12 | P39900 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 3/20 | 0.41 |
| ▸ | MMP14 | P50281 | 3/20 | 0.41 |
| ▸ | MMP16 | P51512 | 3/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10040108 | 0.87 | HTR6 (0.74) | HTR6ACLY | |
| SCHEMBL10040111 | 0.81 | HTR6 (1.00) | HTR6ACLYMMP1MMP2MMP3 | |
| SCHEMBL10040156 | 0.72 | HTR6 (0.61) | HTR6MMP1MMP2MMP3MMP9 | |
| SCHEMBL10040087 | 0.70 | HTR6 (1.00) | HTR6 | |
| SCHEMBL5457309 | 0.69 | ACLY (0.56) | ACLY | |
| SCHEMBL3026340 | 0.68 | HTR6 (0.74) | HTR6MMP1MMP2MMP3MMP9 | |
| (Phenylsulfonyl)Benzene SCHEMBL28196220 | 0.68 | HTR6 (0.74) | HTR6MMP1MMP2MMP3MMP9 | |
| SCHEMBL20198254 | 0.68 | HTR6 (0.58) | HTR6MMP1MMP2MMP3MMP9 | |
| SCHEMBL11577144 | 0.68 | HTR6 (0.45) | HTR6 | |
| SCHEMBL15307422 | 0.68 | KIF18A (0.68) | HTR6MMP1MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3072882-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF | Alla Chem, LLC. (US) | 2016-09-28 | — | — | EP | disclosed |
| US-8829002-B2 | Substituted methyl amines, serotonin 5-HT6 receptor antagonists, methods for production and use thereof | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2014-09-09 | — | — | US | disclosed |
| US-8829002-B2 | Substituted methyl amines, serotonin 5-HT6 receptor antagonists, methods for production and use thereof | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2014-09-09 | — | — | US | disclosed |
| EP-2657225-A2 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF | Ivachtchenko, Alexandre Vasilievich (RU) | 2013-10-30 | — | — | EP | disclosed |
| US-20130267536-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF | ALLA CHEM, LLC (US) | 2013-10-10 | — | — | US | disclosed |
| US-20130267536-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF | ALLA CHEM, LLC (US) | 2013-10-10 | — | — | US | disclosed |
| WO-2012087182-A2 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ, ЛЛС (US) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130267536-A1 | SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF | HTR6, HTR1F, HTR1A | HTR6 1/4885ACLY 3631/4885MMP1 4381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.