Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.49 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.49 |
| ▸ | PTAFR | P25105 | 18/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Etizolam SCHEMBL28142121 | 0.92 | OPRK1 (0.69) | OPRK1PDE4DGABRA1GABRG2HTR2A | |
| Etizolam SCHEMBL28086661 | 0.79 | OPRK1 (0.85) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| SCHEMBL8928407 | 0.77 | OPRK1 (0.79) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| Etizolam SCHEMBL30665015 | 0.76 | OPRK1 (1.00) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| Etizolam SCHEMBL42920 | 0.76 | OPRK1 (1.00) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| Quazepam SCHEMBL28142863 | 0.75 | PTAFR (0.61) | OPRK1PDE4DGABRA1GABRG2HTR2A | |
| Fletazepam SCHEMBL119540 | 0.74 | CYP3A4 (0.48) | OPRK1PDE4DADRA1ACYP3A4 | |
| Etizolam SCHEMBL10869413 | 0.74 | OPRK1 (0.90) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| Triazolam SCHEMBL5967518 | 0.73 | GABRA1 (0.75) | OPRK1PDE4DGABRA1GABRG2HTR2A | |
| Flurazepam SCHEMBL6130059 | 0.73 | OPRK1 (0.76) | OPRK1PDE4DGABRA1GABRG2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593104-A2 | METHODS OF TREATING AND PREVENTING/REDUCING THE LIKELIHOOD OF MESIAL TEMPORAL LOBE EPILEPSY (TLE) | Müller, Prof. Dr., Wolfgang (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2011011692-A2 | METHODS OF TREATING AND PREVENTING/REDUCING THE LIKELIHOOD OF MESIAL TEMPORAL LOBE EPILEPSY (TLE) | STC.UNM (US) | 2011-01-27 | — | — | WO | disclosed |