Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 2/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.31 |
| ▸ | HPD | P32754 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10069593 | 0.83 | MEN1 (0.35) | ADORA2AMAPK14HPD | |
| SCHEMBL10069608 | 0.83 | HPD (0.32) | MAPK14HPD | |
| SCHEMBL10069609 | 0.82 | LMNA (0.34) | LMNATHRBKDM5BMAPK14HPD | |
| SCHEMBL10069626 | 0.82 | HPD (0.34) | MAPK14HPDPOLBALDH1A1 | |
| SCHEMBL10069624 | 0.82 | GHSR (0.33) | MAPK14HPD | |
| SCHEMBL10069618 | 0.81 | PTGER1 (0.35) | MAPK14HPD | |
| SCHEMBL10069616 | 0.81 | ALDH1A1 (0.36) | ADORA2ALMNATHRBKDM5APOLB | |
| SCHEMBL10069596 | 0.71 | MAPT (0.36) | LMNATHRBMAPK14POLBMAPT | |
| SCHEMBL10069594 | 0.70 | MAPT (0.38) | LMNAMAPTALDH1A1 | |
| SCHEMBL10069619 | 0.67 | KDM5B (0.34) | ADORA2AKDM5BADORA3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047993-A2 | N-HYDROXYPYRIMIDINE-2,4-DIONES AS INHIBITORS OF HIV AND HCV | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2012-04-12 | — | — | WO | disclosed |