Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HPD | P32754 | 3/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 3/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | GNRHR | P30968 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10069593 | 0.83 | MEN1 (0.35) | MEN1KMT2AHPDMAPK14 | |
| SCHEMBL10069608 | 0.83 | HPD (0.32) | HPDMAPK14 | |
| SCHEMBL10069628 | 0.82 | ALDH1A1 (0.35) | LMNAMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL10069607 | 0.82 | ADORA2A (0.35) | LMNAPOLBALDH1A1HPDMAPK14 | |
| SCHEMBL10069626 | 0.82 | HPD (0.34) | POLBALDH1A1HPDMAPK14MAPK1 | |
| SCHEMBL10069624 | 0.82 | GHSR (0.33) | TDP1HPDMAPK14GRM4 | |
| SCHEMBL10069618 | 0.81 | PTGER1 (0.35) | MEN1KMT2AHPDMAPK14MAPK1 | |
| SCHEMBL10069604 | 0.81 | ERCC5 (0.38) | LMNAPOLBALDH1A1TDP1KDM5B | |
| SCHEMBL10069605 | 0.73 | CNR1 (0.34) | GNRHR | |
| SCHEMBL10069596 | 0.71 | MAPT (0.36) | LMNAPOLBMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047993-A2 | N-HYDROXYPYRIMIDINE-2,4-DIONES AS INHIBITORS OF HIV AND HCV | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2012-04-12 | — | — | WO | disclosed |