Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 11/20 | 0.46 |
| ▸ | FNTB | P49356 | 11/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744106 | 0.82 | FNTA (0.60) | FNTAFNTBCYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL7746020 | 0.81 | FNTA (0.59) | FNTAFNTBCYP11B1CYP11B2 | |
| SCHEMBL8480547 | 0.76 | FNTA (0.58) | FNTAFNTBCYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL7744123 | 0.75 | FNTA (0.57) | FNTAFNTBCYP11B1CYP11B2 | |
| SCHEMBL10101654 | 0.71 | KMT2A (0.50) | CDK4CCND1KMT2AHDAC1HDAC6 | |
| SCHEMBL7738201 | 0.71 | FNTA (0.49) | FNTAFNTBCYP11B1CYP11B2 | |
| SCHEMBL9090521 | 0.68 | TAAR1 (0.48) | FNTAFNTBTAAR1TRPM5ALDH1A1 | |
| SCHEMBL9501323 | 0.68 | ALDH1A1 (0.58) | TAAR1TRPM5ALDH1A1ALOX15MEN1 | |
| SCHEMBL12544753 | 0.68 | CYP11B1 (0.72) | CYP11B1CYP11B2 | |
| SCHEMBL29558 | 0.67 | ALDH1A1 (0.66) | TAAR1TRPM5ALDH1A1ALOX15MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028940-A1 | FUNCTIONALLY SELECTIVE AZANITRILE ALPHA-2C ADRENORECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028940-A1 | FUNCTIONALLY SELECTIVE AZANITRILE ALPHA-2C ADRENORECEPTOR AGONISTS | ADRA2C, ADRB2, ADRA2A | FNTA 1666/4885FNTB 1724/4885TAAR1 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.