Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.41 |
| ▸ | HTR3B | O95264 | 4/20 | 0.41 |
| ▸ | HTR3A | P46098 | 4/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972407 | 0.80 | CYP2B6 (0.35) | CHRM2CHRM1ALDH1A1TSHRKCNH2 | |
| SCHEMBL11757825 | 0.76 | SIGMAR1 (0.41) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL569963 | 0.75 | SIGMAR1 (0.48) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9090858 | 0.73 | SIGMAR1 (0.47) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8411629 | 0.73 | SIGMAR1 (0.47) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL2431449 | 0.73 | CYP2B6 (0.43) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL27513879 | 0.73 | CHRM2 (0.47) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8579465 | 0.72 | MAOA (0.36) | CYP2B6 | |
| SCHEMBL9202300 | 0.72 | CHRM2 (0.46) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL2697321 | 0.72 | CYP2B6 (0.66) | SIGMAR1HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492369-B2 | DRUG ABRUSE | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-12-10 | — | — | US | claimed |
| US-20020019399-A1 | Therapeutic agents for drug dependence | SANTEN PHARMACEUTICAL CO. LTD. (JP) | 2002-02-14 | — | — | US | claimed |
| EP-1130018-A1 | DRUG DEPENDENCE REMEDIES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-09-05 | — | — | EP | claimed |
| JP-10120569-A | — | — | None | — | — | JP | disclosed |
| JP-7089949-A | — | — | None | — | — | JP | disclosed |
| US-8183374-B2 | Piperidine and piperazine derivatives | M'S SCIENCE CORPORATION (JP) | 2012-05-22 | — | — | US | disclosed |
| EP-1988902-B1 | PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2011-11-23 | — | — | EP | disclosed |
| US-20110281890-A1 | Piperidine and piperazine derivatives | M'S SCIENCE CORPORATION | 2011-11-17 | — | — | US | disclosed |
| EP-1978959-B1 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2011-11-09 | — | — | EP | disclosed |
| US-20110269775-A1 | Piperazine derivatives | M'S SCIENCE CORPORATION | 2011-11-03 | — | — | US | disclosed |
| US-20110218205-A1 | Piperazine derivatives | M'S SCIENCE CORP. | 2011-09-08 | — | — | US | disclosed |
| EP-1130018-A1 | DRUG DEPENDENCE REMEDIES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-09-05 | — | — | EP | disclosed |
| EP-1130018-A1 | DRUG DEPENDENCE REMEDIES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-09-05 | — | — | EP | disclosed |
| EP-0711763-B1 | 1,4-DI(PHENYLALKYL)PIPERAZINE DERIVATIVES | SANTEN PHARMACEUTICAL CO LTD (JP) | 2000-10-18 | — | — | EP | disclosed |
| JP-2000204041-A | THERAPEUTIC AGENT FOR DRUG DEPENDENCE | SANTEN PHARMACEUT CO LTD | 2000-07-25 | — | — | JP | disclosed |
| WO-2000027833-A1 | DRUG DEPENDENCE REMEDIES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2000-05-18 | — | — | WO | disclosed |
| JP-H10120569-A | PREVENTIVE AND THERAPEUTIC AGENT FOR EYE DISEASE | SANTEN PHARMACEUT CO LTD | 1998-05-12 | — | — | JP | disclosed |
| US-5736546-A | BRAIN DISORDERS; PSYCHOLOGICAL DISORDERS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1998-04-07 | — | — | US | disclosed |
| EP-0711763-A1 | NOVEL 1,4-DI(PHENYLALKYL)PIPERAZINE DERIVATIVE | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1996-05-15 | — | — | EP | disclosed |
| JP-H0789949-A | NOVEL 1,4-(DIPHENYLALKYL)PIPERAZINE DERIVATIVE | SANTEN PHARMACEUT CO LTD | 1995-04-04 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269775-A1 | Piperazine derivatives | SIGMAR1, OPRK1, OPRL1 | SIGMAR1 1/4885HTR3E 582/4885HTR3B 212/4885 |
| US-20020019399-A1 | Therapeutic agents for drug dependence | ADH1A, ADH1C, ADH5 | SIGMAR1 15/4885HTR3E 1203/4885HTR3B 775/4885 |
| US-20110281890-A1 | Piperidine and piperazine derivatives | SIGMAR1, OPRM1, OPRD1 | SIGMAR1 1/4885HTR3E 274/4885HTR3B 89/4885 |
| US-20110218205-A1 | Piperazine derivatives | SIGMAR1, OPRK1, OPRM1 | SIGMAR1 1/4885HTR3E 834/4885HTR3B 232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.