Sugi Predict

Sugi Predict / Compounds / SCHEMBL1013306

SCHEMBL1013306

SCHEMBL1013306

Cc1ccc(NC(=O)Oc2ccccc2)cn1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.60
▸ MAPT P10636 3/20 0.60
▸ MEN1 O00255 2/20 0.56
▸ KMT2A Q03164 2/20 0.56
▸ KDM4E B2RXH2 2/20 0.56
▸ THRB P10828 1/20 0.56
▸ GFER P55789 1/20 0.56
▸ TDP1 Q9NUW8 1/20 0.56
▸ PORCN Q9H237 2/20 0.55
▸ RAD51 Q06609 1/20 0.55
▸ GAA P10253 3/20 0.55
▸ LMNA P02545 1/20 0.55
▸ TP53 P04637 1/20 0.55
▸ HTT P42858 1/20 0.53
▸ SMN1; SMN2 Q16637 1/20 0.53
▸ FAAH O00519 6/20 0.52
▸ MAPKAPK2 P49137 1/20 0.52
▸ CYP1A2 P05177 1/20 0.51
▸ POLB P06746 1/20 0.50
▸ CCNE1 P24864 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29644563 1.00 ALDH1A1 (0.60) ALDH1A1MAPTMEN1KMT2AKDM4E
Hydrochloric Acid SCHEMBL29644534 0.98 ALDH1A1 (0.59) ALDH1A1MAPTMEN1KMT2AKDM4E
Hydrochloric Acid SCHEMBL31090358 0.98 ALDH1A1 (0.59) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL29021371 0.85 ALDH1A1 (0.60) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL24757867 0.84 ALDH1A1 (0.59) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL20380072 0.84 NAMPT (0.56) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL896314 0.83 KCNQ3 (0.64) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL590618 0.82 KMT2A (0.61) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL1010493 0.82 ALDH1A1 (0.56) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL31728525 0.82 ALDH1A1 (0.56) ALDH1A1MAPTMEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240217933-A1 HETEROCYCLIC COMPOUNDS AND THEIR USES AMGEN INC. 2024-07-04 — — US disclosed
US-20230373955-A1 SYNTHESIS OF OMECAMTIV MECARBIL AMGEN INC. 2023-11-23 — — US disclosed
EP-4265597-A2 SYNTHESIS OF OMECAMTIV MECARBIL Amgen Inc. (US) 2023-10-25 — — EP disclosed
US-11753394-B2 Synthesis of omecamtiv mecarbil AMGEN INC. (US) 2023-09-12 — — US disclosed
US-11753394-B2 Synthesis of omecamtiv mecarbil AMGEN INC. (US) 2023-09-12 — — US disclosed
EP-3925950-B1 SYNTHESIS OF OMECAMTIV MECARBIL AMGEN INC (US) 2023-09-06 — — EP disclosed
US-11702380-B2 Synthesis of omecamtiv mecarbil AMGEN INC. (US) 2023-07-18 — — US disclosed
US-11702380-B2 Synthesis of omecamtiv mecarbil AMGEN INC. (US) 2023-07-18 — — US disclosed
CN-110799503-B Synthesis of Meicartine 美国安进公司 2023-06-27 — — CN disclosed
US-20230044617-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT CYTOKINETICS, INC. 2023-02-09 — — US disclosed
US-20140309235-A1 HETEROCYCLIC COMPOUNDS AND THEIR USES CYTOKINETICS, INC. (US) 2014-10-16 — — US disclosed
WO-2014152236-A1 HETEROCYCLIC COMPOUNDS AND THEIR USES AMGEN INC. (US) 2014-09-25 — — WO disclosed
WO-2014152270-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT AMGEN INC. (US) 2014-09-25 — — WO disclosed
WO-2014152198-A1 HETEROCYCLIC COMPOUNDS AND THEIR USES AMGEN INC. (US) 2014-09-25 — — WO disclosed
US-20120083476-A1 HETEROARYL-SUBSTITUTED SPIROCYCLIC DIAMINE UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2012-04-05 — — US disclosed
US-8044052-B2 Inhibitors of fatty acid amide hydrolase; N-pyridin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxamide; elevate brain anandamide levels; pain, urinary incontinence, cognitive disorders, anxiety, depression, sleeping, eating, movement disorders, glaucoma, psoriasis PFIZER INC. (US) 2011-10-25 — — US disclosed
EP-2076508-B1 BIARYL ETHER UREA COMPOUNDS PFIZER PROD INC (US) 2011-01-05 — — EP disclosed
EP-2076508-A2 BIARYL ETHER UREA COMPOUNDS Pfizer Products Inc. (US) 2009-07-08 — — EP disclosed
US-20080261941-A1 Biaryl Ether Urea Compounds Jazz Pharmaceuticals Therapeutics, Inc. 2008-10-23 — — US disclosed
WO-2008047229-A2 BIARYL ETHER UREA COMPOUNDS PFIZER PRODUCTS INC. (US) 2008-04-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230044617-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT SI, SLC5A6, SLC28A1 ALDH1A1 1835/4885MAPT 2385/4885MEN1 348/4885
US-11702380-B2 Synthesis of omecamtiv mecarbil SI, MTHFD2, DPYD ALDH1A1 1017/4885MAPT 3660/4885MEN1 691/4885
US-20140309235-A1 HETEROCYCLIC COMPOUNDS AND THEIR USES SI, MLN, MLNR ALDH1A1 1507/4885MAPT 3947/4885MEN1 295/4885
US-20230373955-A1 SYNTHESIS OF OMECAMTIV MECARBIL DPYD, SI, MTHFD2 ALDH1A1 570/4885MAPT 2656/4885MEN1 644/4885
US-11753394-B2 Synthesis of omecamtiv mecarbil SI, DPYD, MTHFD2 ALDH1A1 703/4885MAPT 2694/4885MEN1 827/4885
US-20120083476-A1 HETEROARYL-SUBSTITUTED SPIROCYCLIC DIAMINE UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, DBH ALDH1A1 709/4885MAPT 1489/4885MEN1 3933/4885
US-20080261941-A1 Biaryl Ether Urea Compounds FAAH, FAAH2, LIPC ALDH1A1 360/4885MAPT 1768/4885MEN1 4102/4885
US-20240217933-A1 HETEROCYCLIC COMPOUNDS AND THEIR USES SI, MLN, MLNR ALDH1A1 1507/4885MAPT 3947/4885MEN1 295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.