SCHEMBL10140139

SCHEMBL10140139

CNC(=O)c1cc(Br)cc(C)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1C

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CARM1 Q86X55 3/20 0.38
SORT1 Q99523 1/20 0.38
TP53 P04637 1/20 0.37
KDM4E B2RXH2 1/20 0.37
MEN1 O00255 1/20 0.37
ALDH1A1 P00352 1/20 0.37
MAPT P10636 1/20 0.37
KMT2A Q03164 1/20 0.37
LMNA P02545 1/20 0.37
POLB P06746 1/20 0.37
CRACR2A Q9BSW2 2/20 0.36
F10 P00742 3/20 0.36
F2 P00734 2/20 0.36
KLKB1 P03952 1/20 0.35
TRPV1 Q8NER1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL782214 0.92 CARM1 (0.38) CARM1TP53KDM4EMEN1ALDH1A1
SCHEMBL10140135 0.91 CARM1 (0.37) CARM1SORT1TP53KDM4EMEN1
SCHEMBL10140166 0.89 CARM1 (0.38) CARM1TP53KDM4EMEN1ALDH1A1
SCHEMBL10140148 0.88 SORT1 (0.41) SORT1TP53KDM4EMEN1ALDH1A1
SCHEMBL10140212 0.87 CARM1 (0.38) CARM1TP53KDM4EMEN1ALDH1A1
SCHEMBL11891967 0.87 CARM1 (0.36) CARM1TP53KDM4EMEN1ALDH1A1
SCHEMBL10140154 0.86 SORT1 (0.39) SORT1TP53KDM4EMEN1ALDH1A1
SCHEMBL10140216 0.85 PDE4B (0.37) CARM1TP53KDM4EMEN1ALDH1A1
SCHEMBL10028769 0.84 CARM1 (0.39) CARM1KDM4EMEN1ALDH1A1MAPT
SCHEMBL15244619 0.84 PDE4B (0.40) CARM1KDM4EMEN1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9949482-B2 Fungicidal compositions SYNGENTA CROP PROTECTION, LLC (US) 2018-04-24 US disclosed
US-20170071205-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, LLC (US) 2017-03-16 US disclosed
US-9538755-B2 Fungicidal compositions SYNGENTA CROP PROTECTION, LLC (US) 2017-01-10 US disclosed
US-9282743-B2 Chemical compounds SYNGENTA PARTICIPATIONS AG (CH) 2016-03-15 US disclosed
US-9096525-B2 Iminipyridine derivatives and their uses as microbiocides SYNGENTA CROP PROTECTION, LLC (US) 2015-08-04 US disclosed
US-20140051736-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, LLC (US) 2014-02-20 US disclosed
US-8536089-B2 For controlling phytopathogenic diseases; synergistic SYNGENTA CROP PROTECTION LLC (US) 2013-09-17 US disclosed
US-20130210625-A1 SPIROHETEROCYCLIC PYRROLIDINE DERIVATIVES BASED PESTICIDES SYNGENTA CROP PROTECTION LLC (US) 2013-08-15 US disclosed
US-8124566-B2 Synergistic fungicidal compositions SYNGENTA CROP PROTECTION, INC. (US) 2012-02-28 US disclosed
US-8124567-B2 Fungicidal compositions SYNGENTA CROP PROTECTION, INC. (US) 2012-02-28 US disclosed
US-20080076664-A1 Fungicidal Compositions SYNGENTA CROP PROTECTION, INC. 2008-03-27 US disclosed
US-20080070785-A1 For controlling phytopathogenic diseases; synergistic SYNGENTA CROP PROTECTION, INC. (US) 2008-03-20 US disclosed
US-20070265267-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, INC. (US) 2007-11-15 US disclosed
US-20070244121-A1 Synergistic Fungicidal Compositions SYNGENTA CROP PROTECTION, INC. (US) 2007-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051736-A1 FUNGICIDAL COMPOSITIONS PIK3C3, CYP51A1, CYP1B1 CARM1 2370/4885SORT1 545/4885TP53 3640/4885
US-20130210625-A1 SPIROHETEROCYCLIC PYRROLIDINE DERIVATIVES BASED PESTICIDES DDT, PYCR1, PKD2 CARM1 1438/4885SORT1 3180/4885TP53 2499/4885
US-20070265267-A1 FUNGICIDAL COMPOSITIONS CRY1, ERG28, DDT CARM1 832/4885SORT1 2817/4885TP53 4665/4885
US-20070244121-A1 Synergistic Fungicidal Compositions DDT, CRY1, HCN1 CARM1 1036/4885SORT1 2972/4885TP53 4725/4885
US-20080070785-A1 For controlling phytopathogenic diseases; synergistic BROX, EPM2A, MANBA CARM1 3494/4885SORT1 639/4885TP53 3380/4885
US-20170071205-A1 FUNGICIDAL COMPOSITIONS PIK3C3, CYP51A1, CYP1B1 CARM1 2370/4885SORT1 545/4885TP53 3640/4885
US-20080076664-A1 Fungicidal Compositions AKR7A2, CYP51A1, TUBA3C CARM1 2578/4885SORT1 2459/4885TP53 4397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.