Sugi Predict

Sugi Predict / Compounds / SCHEMBL10144263

SCHEMBL10144263

SCHEMBL10144263

C#C/C(C#N)=C/c1cc(O)c(O)c(O)c1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EGFR P00533 9/20 0.78
▸ MEN1 O00255 8/20 0.78
▸ KMT2A Q03164 8/20 0.78
▸ MAPT P10636 8/20 0.78
▸ ALDH1A1 P00352 7/20 0.78
▸ HPGD P15428 6/20 0.78
▸ BLM P54132 6/20 0.78
▸ KDM4E B2RXH2 6/20 0.78
▸ LMNA P02545 6/20 0.78
▸ CYP3A4 P08684 5/20 0.78
▸ CYP2C9 P11712 5/20 0.78
▸ HSD17B10 Q99714 5/20 0.78
▸ ALOX15 P16050 4/20 0.78
▸ NFKB1 P19838 4/20 0.78
▸ PMP22 Q01453 4/20 0.78
▸ SMN1; SMN2 Q16637 4/20 0.78
▸ HIF1A Q16665 4/20 0.78
▸ TDP1 Q9NUW8 4/20 0.78
▸ RGS12 O14924 3/20 0.78
▸ GNAI1 P63096 3/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25736028 0.88 EGFR (0.61) EGFRMEN1KMT2AMAPTALDH1A1
Tyrphostin 25 SCHEMBL239879 0.88 EGFR (1.00) EGFRMEN1KMT2AMAPTALDH1A1
SCHEMBL10144274 0.82 ALDH1A1 (0.84) EGFRMEN1KMT2AMAPTALDH1A1
SCHEMBL10144262 0.81 EGFR (0.79) EGFRMEN1KMT2AMAPTALDH1A1
SCHEMBL23252516 0.76 EGFR (0.54) EGFRMEN1KMT2AMAPTALDH1A1
SCHEMBL10186359 0.76 EGFR (1.00) EGFRMEN1KMT2AMAPTALDH1A1
SCHEMBL8485552 0.76 EGFR (0.75) EGFRMEN1KMT2AMAPTALDH1A1
SCHEMBL25736025 0.74 MEN1 (0.77) EGFRMEN1KMT2AMAPTALDH1A1
SCHEMBL29457559 0.73 EGFR (1.00) EGFRMEN1KMT2AMAPTALDH1A1
SCHEMBL3459584 0.73 EGFR (1.00) EGFRMEN1KMT2AMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240024490-A1 BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES THE BROAD INSTITUTE, INC. 2024-01-25 — — US disclosed
US-20230192904-A1 BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF THE BROAD INSTITUTE, INC. 2023-06-22 — — US disclosed
US-20120022116-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX CORNING INCORPORATED 2012-01-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120022116-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX GPR35, GPR65, GPR68 EGFR 2861/4885MEN1 4026/4885KMT2A 4109/4885
US-20240024490-A1 BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES COASY, JMJD7, PTMS EGFR 3560/4885MEN1 3675/4885KMT2A 2272/4885
US-20230192904-A1 BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF ERBB2, ACP1, TK1 EGFR 220/4885MEN1 3627/4885KMT2A 1636/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.