Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 6/20 | 0.40 |
| ▸ | RXRA | P19793 | 5/20 | 0.40 |
| ▸ | RXRG | P48443 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MYC | P01106 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | EEF2K | O00418 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10123683 | 0.83 | RXRA (0.39) | RXRBRXRARXRGALDH1A1MYC | |
| SCHEMBL10148986 | 0.68 | RXRA (0.44) | RXRBRXRAALDH1A1POLBMEN1 | |
| SCHEMBL10149042 | 0.65 | RXRA (0.48) | RXRBRXRARXRGALDH1A1MEN1 | |
| SCHEMBL10148371 | 0.65 | KDM4E (0.36) | RXRBRXRARXRGALDH1A1POLB | |
| SCHEMBL10123784 | 0.64 | XDH (0.40) | RXRBRXRA | |
| SCHEMBL11728495 | 0.63 | ALDH1A1 (0.47) | RXRBRXRARXRGALDH1A1POLB | |
| SCHEMBL10148487 | 0.62 | KDM4E (0.38) | RXRBRXRAALDH1A1KDM4EHSD17B10 | |
| Terephthalic Acid SCHEMBL4543853 | 0.62 | TSHR (0.52) | RXRBRXRARXRGALDH1A1POLB | |
| SCHEMBL10148361 | 0.61 | NOS3 (0.40) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL3980033 | 0.60 | METAP2 (0.57) | RXRBRXRARXRGALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415771-A1 | INDOLIZINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | Kissei Pharmaceutical Co., Ltd. (JP) | 2012-02-08 | — | — | EP | disclosed |