SCHEMBL10173306

SCHEMBL10173306

CC(=O)CCCCCN1C(=O)C=CC1=O

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 7/20 0.70
PTGS2 P35354 7/20 0.70
MGLL Q99685 7/20 0.65
FAAH O00519 5/20 0.65
MAPK1 P28482 2/20 0.65
HSP90AA1 P07900 1/20 0.65
TLR9 Q9NR96 1/20 0.65
ALDH1A1 P00352 1/20 0.65
LMNA P02545 1/20 0.65
TP53 P04637 1/20 0.65
MAPT P10636 1/20 0.65
PKM P14618 1/20 0.65
HPGD P15428 1/20 0.65
XBP1 P17861 1/20 0.65
HTT P42858 1/20 0.65
RECQL P46063 1/20 0.65
RAB9A P51151 1/20 0.65
SMN1; SMN2 Q16637 1/20 0.65
NPSR1 Q6W5P4 1/20 0.65
GPR35 Q9HC97 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22237613 1.00 PTGS1 (0.70) PTGS1PTGS2MGLLFAAHMAPK1
SCHEMBL24637632 1.00 PTGS1 (0.70) PTGS1PTGS2MGLLFAAHMAPK1
SCHEMBL14968624 1.00 PTGS1 (0.70) PTGS1PTGS2MGLLFAAHMAPK1
SCHEMBL14524212 0.98 PTGS1 (0.67) PTGS1PTGS2MGLLFAAHMAPK1
SCHEMBL10014802 0.92 MGLL (0.60) PTGS1PTGS2MGLLFAAHMAPK1
SCHEMBL19201659 0.88 PTGS1 (0.56) PTGS1PTGS2MGLLFAAHMAPK1
SCHEMBL18515827 0.88 PTGS1 (0.56) PTGS1PTGS2MGLLFAAHMAPK1
SCHEMBL15354307 0.84 PTGS1 (0.55) PTGS1PTGS2MGLLFAAHMAPK1
Acetic Acid SCHEMBL27987918 0.84 PTGS1 (0.69) PTGS1PTGS2MGLLFAAHMAPK1
SCHEMBL2734915 0.84 MGLL (0.52) PTGS1PTGS2MGLLFAAHMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 206 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024151890-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PROFOUNDBIO US CO. (US) 2024-07-18 WO disclosed
US-20240218011-A1 GLUCOCORTICOID RECEPTOR AGONISTS AND CONJUGATES THEREOF FIREFLY BIO, INC. 2024-07-04 US disclosed
WO-2024141575-A1 ANTIBODY-DRUG CONJUGATES TARGETING UPARAP COMPRISING EXATECAN DERIVATIVES ADCENDO APS (DK) 2024-07-04 WO disclosed
US-20240207429-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME WILMINGTON TRUST, NATIONAL ASSOCIATION 2024-06-27 US disclosed
WO-2024129756-A1 SITE-SPECIFIC ENGINEERED CYSTEINE ANTIBODY DRUG CONJUGATES SEAGEN INC. (US) 2024-06-20 WO disclosed
WO-2024130161-A2 NOVEL CAMPTOTHECIN DERIVATIVES AND CONJUGATES THEREOF BIONECURE THERAPEUTICS INC (US) 2024-06-20 WO disclosed
WO-2024110905-A1 ANTI-CEA ANTIBODY DRUG CONJUGATES AND METHODS OF USE BEIGENE, LTD. (KY) 2024-05-30 WO disclosed
WO-2024044554-A1 VHH ANTIBODY CONJUGATES WITH HETEROARYL CHELATORS Abdera Therapeutics Inc. (US) 2024-02-29 WO disclosed
WO-2024044549-A1 VHH ANTIBODY CONJUGATES Abdera Therapeutics Inc. (US) 2024-02-29 WO disclosed
WO-2024044552-A1 VHH ANTIBODY DOTA CONJUGATES Abdera Therapeutics Inc. (US) 2024-02-29 WO disclosed
US-20120034246-A1 MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS SEATTLE GENETICS, INC. (US) 2012-02-09 US disclosed
US-20110288011-A1 PEPTIDE THERAPEUTIC CONJUGATES AND USES THEREOF ANGIOCHEM INC. (CA) 2011-11-24 US disclosed
EP-2353611-A2 Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease Seattle Genetics, Inc. (US) 2011-08-10 EP disclosed
US-20110064753-A1 DRUG CONJUGATES AND THEIR USE FOR TREATING CANCER, AN AUTOIMMUNE DISEASE OR AN INFECTIOUS DISEASE SEATTLE GENETICS, INC. (US) 2011-03-17 US disclosed
US-7851437-B2 monoclonal antibody conjugated with peptide drug such as dolastatin derivative SEATTLE GENETICS INC. (US) 2010-12-14 US disclosed
US-20100256055-A1 CONJUGATES OF NEUROTENSIN OR NEUROTENSIN ANALOGS AND USES THEREOF ANGIOCHEM INC. (CA) 2010-10-07 US disclosed
US-20100062008-A1 monoclonal antibody conjugated with peptide drug such as dolastatin derivative SEATTLE GENETICS, INC. (US) 2010-03-11 US disclosed
US-7659241-B2 monoclonal antibody conjugated with peptide drug such as dolastatin derivative SEATTLE GENETICS, INC. (US) 2010-02-09 US disclosed
US-20090155289-A1 FURIN-CLEAVABLE PEPTIDE LINKERS FOR DRUG-LIGAND CONJUGATES PANACEA PHARMACEUTICALS, INC. 2009-06-18 US disclosed
WO-2008136888-A2 SECOND GENERATION LOW OXYGEN AFFINITY PEGYLATED HEMOGLOBINS AS OXYGEN-CARRYING PLASMA EXPANDERS ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) 2008-11-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110064753-A1 DRUG CONJUGATES AND THEIR USE FOR TREATING CANCER, AN AUTOIMMUNE DISEASE OR AN INFECTIOUS DISEASE CD47, CD2, CD22 PTGS1 3090/4885PTGS2 3364/4885MGLL 3949/4885
US-20240218011-A1 GLUCOCORTICOID RECEPTOR AGONISTS AND CONJUGATES THEREOF NR3C1, NR3C2, MC2R PTGS1 605/4885PTGS2 1013/4885MGLL 2283/4885
US-20100062008-A1 monoclonal antibody conjugated with peptide drug such as dolastatin derivative DAD1, DDOST, STT3A PTGS1 3909/4885PTGS2 4445/4885MGLL 2132/4885
US-20100256055-A1 CONJUGATES OF NEUROTENSIN OR NEUROTENSIN ANALOGS AND USES THEREOF NTSR1, NTSR2, NPY1R PTGS1 2387/4885PTGS2 2777/4885MGLL 4474/4885
US-20240207429-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PAICS, DHFR, CD44 PTGS1 4504/4885PTGS2 4518/4885MGLL 3959/4885
US-20120034246-A1 MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS MMAB, CAD, VIM PTGS1 4742/4885PTGS2 4834/4885MGLL 4454/4885
US-20110288011-A1 PEPTIDE THERAPEUTIC CONJUGATES AND USES THEREOF VIP, SLC1A5, SLC47A1 PTGS1 3954/4885PTGS2 4297/4885MGLL 4648/4885
US-20090155289-A1 FURIN-CLEAVABLE PEPTIDE LINKERS FOR DRUG-LIGAND CONJUGATES FURIN, TGOLN2, LAMP1 PTGS1 4405/4885PTGS2 4559/4885MGLL 2591/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.