Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SLC7A5 | Q01650 | 7/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | ALPI | P09923 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | XIAP | P98170 | 1/20 | 0.51 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.50 |
| ▸ | NOS3 | P29474 | 2/20 | 0.49 |
| ▸ | NOS1 | P29475 | 2/20 | 0.49 |
| ▸ | NOS2 | P35228 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22444630 | 1.00 | KDM4E (0.52) | KDM4ENPC1RAB9ASLC7A5PTGS1 | |
| SCHEMBL22444655 | 0.87 | KDM4E (0.50) | KDM4ENPC1RAB9AGRIA2BCHE | |
| SCHEMBL524638 | 0.83 | ITGB3 (0.59) | KDM4ENPC1RAB9ASLC7A5PTGS1 | |
| SCHEMBL9784912 | 0.83 | ITGB3 (0.59) | KDM4ENPC1RAB9ASLC7A5PTGS1 | |
| SCHEMBL455152 | 0.83 | ITGB3 (0.59) | KDM4ENPC1RAB9ASLC7A5PTGS1 | |
| SCHEMBL25359079 | 0.82 | SLC7A5 (0.56) | SLC7A5PTGS1ALPIPKMXIAP | |
| SCHEMBL2777704 | 0.82 | SLC7A5 (0.58) | KDM4ESLC7A5PTGS1ALPIPKM | |
| SCHEMBL25356665 | 0.82 | SLC7A5 (0.56) | SLC7A5PTGS1ALPIPKMXIAP | |
| Hydrochloric Acid SCHEMBL6775024 | 0.82 | ITGB3 (0.58) | KDM4ESLC7A5PTGS1ALPIPKM | |
| SCHEMBL25355736 | 0.82 | SLC7A5 (0.56) | SLC7A5PTGS1ALPIPKMXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4540267-B1 | CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA | MERCK SHARP & DOHME LLC (US) | 2026-04-15 | — | — | EP | disclosed |
| US-20230406885-A1 | CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA | MERCK SHARP & DOHME LLC (US) | 2023-12-21 | — | — | US | disclosed |
| EP-2796546-B1 | Incorporation of unnatural amino acids | SCRIPPS RESEARCH INST (US) | 2017-08-09 | — | — | EP | disclosed |
| EP-1490483-B1 | IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS | SCRIPPS RESEARCH INST (US) | 2015-06-03 | — | — | EP | disclosed |
| EP-2796546-A1 | In vivo incorporation of unnatural amino acids | The Scripps Research Institute (US) | 2014-10-29 | — | — | EP | disclosed |
| US-20120202243-A1 | IN Vivo Incorporation of Unnatural Amino Acids | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-09 | — | — | US | disclosed |
| US-8173392-B2 | In vivo incorporation of unnatural amino acids | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-05-08 | — | — | US | disclosed |
| US-8114648-B2 | In vivo incorporation of unnatural amino acids | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-02-14 | — | — | US | disclosed |
| US-8030074-B2 | In vivo incorporation of unnatural amino acids | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-10-04 | — | — | US | disclosed |
| EP-2322631-A1 | In vivo incorporation of unnatural amino acids | The Scripps Research Institute (US) | 2011-05-18 | — | — | EP | disclosed |
| US-7915025-B2 | In vivo incorporation of unnatural amino acids | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-03-29 | — | — | US | disclosed |
| US-7638300-B2 | Translation systems with orthogonal aminoacyl tRNA synthetase; membrane proteins | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-12-29 | — | — | US | disclosed |
| US-20090068717-A1 | In vivo incorporation of unnatural amino acids | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
| US-20080261311-A1 | Translation systems with orthogonal aminoacyl tRNA synthetase; membrane proteins | THE SCRIPPS RESEARCH INSTITUTE and THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-10-23 | — | — | US | disclosed |
| US-20080227152-A1 | Translation systems with orthogonal aminoacyl tRNA synthetase; membrane proteins | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-09-18 | — | — | US | disclosed |
| US-20080167243-A1 | immunizing a subject with a sufficient amount of a translated polypeptide to produce antibody; containing a phenylalanine or tyrosine derivative analoges | THE SCRIPPS RESEARCH INSTITUTE | 2008-07-10 | — | — | US | disclosed |
| US-20080166783-A1 | Translation system for biosynthesis of insulin like growth factor | THE SCRIPPS RESEARCH INSTITUTE and THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-07-10 | — | — | US | disclosed |
| US-7368275-B2 | Orthogonal tRNA synthetase that aminoacylates with reduced efficiency; lower km and recognizes selector codon in mRNA | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-05-06 | — | — | US | disclosed |
| US-20070117184-A1 | Translation systems with orthogonal aminoacyl tRNA synthetase; membrane proteins | THE SCRIPPS RESEARCH INSTITUTE | 2007-05-24 | — | — | US | disclosed |
| WO-2007001406-A2 | ARYL-CONTAINING MACROCYCLIC COMPOUNDS | CHIRON CORPORATION (US) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167243-A1 | immunizing a subject with a sufficient amount of a translated polypeptide to produce antibody; containing a phenylalanine or tyrosine derivative analoges | DNPEP, NPEPPS, TYR | KDM4E 1746/4885NPC1 4163/4885RAB9A 3242/4885 |
| US-20230406885-A1 | CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA | IL1A, IL1B, IL1R1 | KDM4E 4454/4885NPC1 1431/4885RAB9A 225/4885 |
| US-20080261311-A1 | Translation systems with orthogonal aminoacyl tRNA synthetase; membrane proteins | AARS1, NSUN3, TRMT1 | KDM4E 3149/4885NPC1 1799/4885RAB9A 2538/4885 |
| US-20070117184-A1 | Translation systems with orthogonal aminoacyl tRNA synthetase; membrane proteins | AARS1, NSUN3, TRMT1 | KDM4E 3149/4885NPC1 1799/4885RAB9A 2538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.