SCHEMBL10198760

SCHEMBL10198760

CONC(=O)CCCCCCC(=O)Nc1ccccc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 18/20 0.66
HDAC8 Q9BY41 18/20 0.66
HDAC6 Q9UBN7 18/20 0.66
HDAC4 P56524 17/20 0.66
HDAC11 Q96DB2 17/20 0.66
HDAC5 Q9UQL6 17/20 0.66
HDAC3 O15379 17/20 0.66
HDAC2 Q92769 17/20 0.66
HDAC7 Q8WUI4 16/20 0.66
HDAC9 Q9UKV0 16/20 0.66
HDAC10 Q969S8 16/20 0.66
CYP3A4 P08684 2/20 0.66
KCNH2 Q12809 2/20 0.66
NCOR2 Q9Y618 2/20 0.66
KDM4E B2RXH2 1/20 0.66
BRD4 O60885 1/20 0.66
NCOR1 O75376 1/20 0.66
NR1I2 O75469 1/20 0.66
EGFR P00533 1/20 0.66
LTA4H P09960 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydroxyamine SCHEMBL1268824 0.86 HDAC6 (0.79) HDAC1HDAC8HDAC6HDAC4HDAC11
SCHEMBL137348 0.86 HDAC4 (0.85) HDAC1HDAC8HDAC6HDAC4HDAC11
SCHEMBL6665592 0.86 HDAC4 (0.85) HDAC1HDAC8HDAC6HDAC4HDAC11
SCHEMBL6669511 0.86 HDAC4 (0.85) HDAC1HDAC8HDAC6HDAC4HDAC11
SCHEMBL1065393 0.86 HDAC4 (0.85) HDAC1HDAC8HDAC6HDAC4HDAC11
SCHEMBL313148 0.85 HDAC4 (0.68) HDAC1HDAC8HDAC6HDAC4HDAC11
SCHEMBL8282876 0.84 HDAC4 (0.63) HDAC1HDAC8HDAC6HDAC4HDAC11
SCHEMBL21710531 0.84 HDAC1 (0.64) HDAC1HDAC8HDAC6HDAC4HDAC11
SCHEMBL517309 0.84 HDAC4 (0.81) HDAC1HDAC8HDAC6HDAC4HDAC11
SCHEMBL541048 0.83 LMNA (0.68) HDAC1HDAC8HDAC6HDAC4HDAC11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022140705-A1 PRODRUGS OF PHARMACEUTICAL AGENTS ALMARSSON ORN (US) 2022-06-30 WO disclosed
US-20200048198-A1 MODIFIED HISTONE DEACETYLASE INHIBITORS AND USES THEREOF UNIV CALIFORNIA (US) 2020-02-13 US disclosed
US-9795597-B2 Cyclopropylamines as LSD1 inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2017-10-24 US disclosed
US-20170239274-A1 COMBINATION NOVARTIS PHARMA AG (CH) 2017-08-24 US disclosed
US-20170189408-A1 NOVEL PHARMACEUTICAL COMPOSITION NOVARTIS AG (CH) 2017-07-06 US disclosed
US-20170020878-A1 COMBINATION COMPRISING A BTK INHIBITOR AND AN AKT INHIBITOR NOVARTIS AG (CH) 2017-01-26 US disclosed
US-20160235714-A1 ENZALUTAMIDE IN COMBINATION WITH AFURESERTIB FOR THE TREATMENT OF CANCER GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) 2016-08-18 US disclosed
US-20160228456-A1 COMBINATION NOVARTIS PHARMA AG (CH) 2016-08-11 US disclosed
US-20160220547-A1 CYCLOPROPYLAMINES AS LSD1 INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2016-08-04 US disclosed
US-9399021-B2 Pharmaceutical composition NOVARTIS AG (CH) 2016-07-26 US disclosed
US-20150342957-A1 COMBINATION GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2015-12-03 US disclosed
US-20150313906-A1 COMBINATION GLAXOSMITHKLINE LLC 2015-11-05 US disclosed
US-9085622-B2 Antigen binding proteins GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2015-07-21 US disclosed
US-8853408-B2 Cyclopropylamines as LSD1 inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) 2014-10-07 US disclosed
US-20140154316-A1 NOVEL PHARMACEUTICAL COMPOSITION GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2014-06-05 US disclosed
US-20140037726-A1 NOVEL PHARMACEUTICAL COMPOSITION GLAXOSMITHKLINE LLC (US) 2014-02-06 US disclosed
US-20140018393-A1 CYCLOPROPYLAMINES AS LSD1 INHIBITORS Glaxo Smith Kline LLC 2014-01-16 US disclosed
US-20130156779-A1 NOVEL ANTIGEN BINDING PROTEINS GLAXO GROUP LIMITED (GB) 2013-06-20 US disclosed
US-20120302579-A1 CANCER TREATMENT METHOD GLAXOSMITHKLINE LLC 2012-11-29 US disclosed
US-20120077828-A1 CHEMICAL COMPOUNDS GLAXOSMITHKLINE LLC 2012-03-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170239274-A1 COMBINATION CYP17A1, HSD17B11, HSD17B1 HDAC1 128/4885HDAC8 289/4885HDAC6 383/4885
US-20160220547-A1 CYCLOPROPYLAMINES AS LSD1 INHIBITORS KDM1B, KDM1A, KDM3B HDAC1 67/4885HDAC8 103/4885HDAC6 175/4885
US-20120302579-A1 CANCER TREATMENT METHOD MPL, TPO, PROKR1 HDAC1 4523/4885HDAC8 4347/4885HDAC6 3697/4885
US-20130156779-A1 NOVEL ANTIGEN BINDING PROTEINS CD2BP2, HSPBP1, LGALS3BP HDAC1 3555/4885HDAC8 2502/4885HDAC6 2378/4885
US-20120077828-A1 CHEMICAL COMPOUNDS BRCA1, IRS1, IGF1R HDAC1 2055/4885HDAC8 4219/4885HDAC6 1050/4885
US-20170020878-A1 COMBINATION COMPRISING A BTK INHIBITOR AND AN AKT INHIBITOR BTK, PIK3CD, PIK3CA HDAC1 842/4885HDAC8 873/4885HDAC6 459/4885
US-20140154316-A1 NOVEL PHARMACEUTICAL COMPOSITION PHOSPHO1, PLA2G2C, TTR HDAC1 1261/4885HDAC8 1585/4885HDAC6 95/4885
US-20140018393-A1 CYCLOPROPYLAMINES AS LSD1 INHIBITORS KDM1B, KDM1A, KDM3B HDAC1 67/4885HDAC8 103/4885HDAC6 175/4885
US-20160228456-A1 COMBINATION CYP17A1, HSD17B11, HSD17B1 HDAC1 143/4885HDAC8 342/4885HDAC6 535/4885
US-20160235714-A1 ENZALUTAMIDE IN COMBINATION WITH AFURESERTIB FOR THE TREATMENT OF CANCER AR, PIK3CA, NR5A1 HDAC1 7/4885HDAC8 23/4885HDAC6 89/4885
US-20140037726-A1 NOVEL PHARMACEUTICAL COMPOSITION PHOSPHO1, PLA2G2C, TTR HDAC1 1261/4885HDAC8 1585/4885HDAC6 95/4885
US-20150313906-A1 COMBINATION EZH2, BMI1, DOT1L HDAC1 16/4885HDAC8 63/4885HDAC6 119/4885
US-20170189408-A1 NOVEL PHARMACEUTICAL COMPOSITION TTR, PHOSPHO1, PLA2G2C HDAC1 1427/4885HDAC8 1470/4885HDAC6 124/4885
US-20200048198-A1 MODIFIED HISTONE DEACETYLASE INHIBITORS AND USES THEREOF HDAC1, HDAC8, HDAC11 HDAC1 1/4885HDAC8 2/4885HDAC6 5/4885
US-20150342957-A1 COMBINATION PAICS, CA6, CA5A HDAC1 67/4885HDAC8 41/4885HDAC6 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.