Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.82 |
| ▸ | HPGD | P15428 | 5/20 | 0.82 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.82 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.82 |
| ▸ | RELA | Q04206 | 5/20 | 0.82 |
| ▸ | LMNA | P02545 | 1/20 | 0.82 |
| ▸ | NPC1 | O15118 | 7/20 | 0.81 |
| ▸ | RAB9A | P51151 | 7/20 | 0.81 |
| ▸ | TP53 | P04637 | 6/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.81 |
| ▸ | CASP3 | P42574 | 4/20 | 0.71 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.71 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.71 |
| ▸ | MMP2 | P08253 | 1/20 | 0.63 |
| ▸ | MMP9 | P14780 | 1/20 | 0.63 |
| ▸ | MMP8 | P22894 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14947173 | 0.92 | ALDH1A1 (0.96) | SMN1; SMN2KDM4EALDH1A1HPGDNFKB1 | |
| SCHEMBL11560753 | 0.90 | KDM4E (1.00) | SMN1; SMN2KDM4EALDH1A1HPGDNFKB1 | |
| SCHEMBL15047797 | 0.90 | ALDH1A1 (0.93) | SMN1; SMN2KDM4EALDH1A1HPGDNFKB1 | |
| SCHEMBL3288386 | 0.90 | ALDH1A1 (1.00) | SMN1; SMN2KDM4EALDH1A1HPGDNFKB1 | |
| SCHEMBL2242771 | 0.87 | NPC1 (0.72) | SMN1; SMN2KDM4EALDH1A1HPGDNFKB1 | |
| SCHEMBL10045311 | 0.85 | ALDH1A1 (0.84) | SMN1; SMN2KDM4EALDH1A1HPGDNFKB1 | |
| SCHEMBL474369 | 0.84 | RAB9A (0.82) | SMN1; SMN2KDM4EALDH1A1HPGDNFKB1 | |
| SCHEMBL2760352 | 0.84 | KDM4E (0.81) | SMN1; SMN2KDM4EALDH1A1HPGDNFKB1 | |
| SCHEMBL10061932 | 0.84 | SMN1; SMN2 (0.81) | SMN1; SMN2KDM4EALDH1A1HPGDNFKB1 | |
| SCHEMBL22103734 | 0.84 | NPC1 (0.81) | SMN1; SMN2KDM4EALDH1A1HPGDNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304409-B2 | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use | NICOX S.A. (FR) | 2012-11-06 | — | — | US | disclosed |
| US-8222277-B2 | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use | NICOX S.A. (FR) | 2012-07-17 | — | — | US | disclosed |
| US-8088762-B2 | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use | NICOX S.A. (FR) | 2012-01-03 | — | — | US | disclosed |
| US-20110098253-A1 | Nitrosated Nonsteroidal Antiinflammatory Compounds, Compositions and Methods of Use | NICOX S.A. (IT) | 2011-04-28 | — | — | US | disclosed |
| US-7754772-B2 | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use | NICOX, S.A. (FR) | 2010-07-13 | — | — | US | disclosed |
| US-20100137291-A1 | NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NICOX SA (FR) | 2010-06-03 | — | — | US | disclosed |
| US-20100093671-A1 | NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NICOX SA (FR) | 2010-04-15 | — | — | US | disclosed |
| US-20100093708-A1 | NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NICOX SA (FR) | 2010-04-15 | — | — | US | disclosed |
| CN-100482717-C | Polybenzole kind aryl ether monomer, copolymer and its synthesis method | JINHUAN LI (CN) | 2009-04-29 | — | — | CN | disclosed |
| US-7163958-B2 | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use | NITROMED INC. (US) | 2007-01-16 | — | — | US | disclosed |
| CN-1869102-A | Polybenzole kind aryl ether monomer, copolymer and its synthesis method | LI JINHUAN (CN) | 2006-11-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093708-A1 | NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NOS2, NOS1, NOS3 | SMN1; SMN2 2338/4885KDM4E 4390/4885ALDH1A1 385/4885 |
| US-20110098253-A1 | Nitrosated Nonsteroidal Antiinflammatory Compounds, Compositions and Methods of Use | NOS2, NOS1, NOS3 | SMN1; SMN2 2499/4885KDM4E 4443/4885ALDH1A1 377/4885 |
| US-20100093671-A1 | NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NOS2, NOS1, NOS3 | SMN1; SMN2 2338/4885KDM4E 4390/4885ALDH1A1 385/4885 |
| US-20100137291-A1 | NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NOS2, NOS1, NOS3 | SMN1; SMN2 2338/4885KDM4E 4390/4885ALDH1A1 385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.