Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | KLK7 | P49862 | 2/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11965182 | 0.88 | CA1 (0.47) | SIRT5CXCR3HDAC4HDAC1HDAC3 | |
| SCHEMBL11953231 | 0.87 | SIRT5 (0.43) | SIRT5CXCR3HDAC4HDAC1HDAC3 | |
| SCHEMBL10253756 | 0.86 | MMP1 (0.40) | SIRT5CXCR3HDAC4HDAC1HDAC3 | |
| SCHEMBL10254540 | 0.83 | JAK3 (0.41) | SIRT5CXCR3HDAC4HDAC1HDAC3 | |
| SCHEMBL880800 | 0.83 | CTSK (0.47) | SIRT5CXCR3CA2ALDH1A1TSHR | |
| SCHEMBL10264028 | 0.83 | CA1 (0.54) | SIRT5CXCR3CA1CA2ALDH1A1 | |
| SCHEMBL10255746 | 0.81 | HDAC4 (0.43) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL10255598 | 0.78 | ADRB2 (0.39) | SIRT5CXCR3HDAC4HDAC1HDAC3 | |
| SCHEMBL11953254 | 0.78 | L3MBTL1 (0.52) | KLK7KLK5CTSKCTSSMAPT | |
| SCHEMBL11953236 | 0.78 | CTSS (0.41) | HDAC4HDAC1HDAC3HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120196933-A1 | MEXILETINE PRODRUGS | FRANKLIN RICHARD (GB) | 2012-08-02 | — | — | US | disclosed |
| WO-2012085586-A1 | MEXILETINE PRODRUGS | SHIRE, LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| US-20110028552-A1 | MEXILETINE AMINO ACID AND PEPTIDE PRODRUGS AND USES THEREOF | SHIRE LLC | 2011-02-03 | — | — | US | disclosed |
| US-20110028552-A1 | MEXILETINE AMINO ACID AND PEPTIDE PRODRUGS AND USES THEREOF | SHIRE LLC | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196933-A1 | MEXILETINE PRODRUGS | SLC16A1, MTPN, SLC16A3 | SIRT5 535/4885CXCR3 4313/4885HDAC4 536/4885 |
| US-20110028552-A1 | MEXILETINE AMINO ACID AND PEPTIDE PRODRUGS AND USES THEREOF | VIP, TRPV1, LNPEP | SIRT5 2307/4885CXCR3 1256/4885HDAC4 1277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.