SCHEMBL10263161

SCHEMBL10263161

COc1ccc(NC(=O)[C@H](CCCCN)NC(=O)c2cc(NC(=O)[C@H](CCCCN)NC(=O)c3cc(NC(=O)[C@H](CCCCN)NC(=O)c4cc(NC(=O)[C@@H](N)CCCNC(=N)N)ccc4OC)ccc3OC)ccc2OC)cc1C(N)=O

nearest known ligand 0.42

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ NPY4R P50391 9/20 0.42
▸ NPY1R P25929 5/20 0.42
▸ ERAP2 Q6P179 5/20 0.41
▸ LNPEP Q9UIQ6 3/20 0.41
▸ ERAP1 Q9NZ08 2/20 0.41
▸ SUV39H2 Q9H5I1 2/20 0.40
▸ NPY2R P49146 4/20 0.40
▸ NPY5R Q15761 4/20 0.40
▸ TERT O14746 2/20 0.38
▸ LTA4H P09960 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10262864 1.00 NPY4R (0.42) NPY4RNPY1RERAP2LNPEPERAP1
SCHEMBL10263133 1.00 NPY4R (0.42) NPY4RNPY1RERAP2LNPEPERAP1
SCHEMBL10262280 1.00 NPY4R (0.42) NPY4RNPY1RERAP2LNPEPERAP1
SCHEMBL19445906 1.00 NPY4R (0.42) NPY4RNPY1RERAP2LNPEPERAP1
SCHEMBL10261836 1.00 NPY4R (0.42) NPY4RNPY1RERAP2LNPEPERAP1
SCHEMBL10262213 1.00 NPY4R (0.42) NPY4RNPY1RERAP2LNPEPERAP1
SCHEMBL19445659 1.00 NPY4R (0.42) NPY4RNPY1RERAP2LNPEPERAP1
SCHEMBL10262715 1.00 NPY4R (0.42) NPY4RNPY1RERAP2LNPEPERAP1
SCHEMBL18116730 0.99 NPY4R (0.41) NPY4RNPY1RERAP2LNPEPERAP1
SCHEMBL19944752 0.98 ERAP2 (0.41) NPY4RNPY1RERAP2LNPEPERAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10603294-B2 Compounds for use in treatment of mucositis INNOVATION PHARMACEUTICALS INC. (US) 2020-03-31 — — US disclosed
US-20190282521-A1 Compounds For Use In Treatment Of Mucositis POLYMEDIX, INC. 2019-09-19 — — US disclosed
US-10206894-B2 Compounds for use in treatment of mucositis INNOVATION PHARMACEUTICALS INC. (US) 2019-02-19 — — US disclosed
US-20180064664-A1 Compounds For Use In Treatment of Mucositis POLYMEDIX, INC. 2018-03-08 — — US disclosed
US-9795575-B2 Compounds for use in treatment of mucositis INNOVATION PHARMACEUTICALS INC. (US) 2017-10-24 — — US disclosed
EP-2709619-B1 COMPOUNDS FOR USE IN TREATMENT OF MUCOSITIS CELLCEUTIX CORP (US) 2017-10-11 — — EP disclosed
US-20170224640-A1 Compounds For Use In Treatment Of Mucositis INNOVATION PHARMACEUTICALS INC. 2017-08-10 — — US disclosed
US-20170224640-A1 Compounds For Use In Treatment Of Mucositis INNOVATION PHARMACEUTICALS INC. 2017-08-10 — — US disclosed
US-9457027-B2 Compounds for use in treatment of mucostis CELLCEUTIX CORPORATION (US) 2016-10-04 — — US disclosed
US-20160213668-A1 Compounds for use in Treatment of Mucostis INNOVATION PHARMACEUTICALS INC. 2016-07-28 — — US disclosed
US-9155738-B2 Compounds for use in treatment of mucostitis CELLCEUTIX CORPORATION (US) 2015-10-13 — — US disclosed
US-20140364364-A1 COMPOUNDS FOR USE IN TREATMENT OF MUCOSITIS INNOVATION PHARMACEUTICALS INC. 2014-12-11 — — US disclosed
US-8802683-B2 Compounds for use in treatment of mucositis CELLCEUTIX CORPORATION (US) 2014-08-12 — — US disclosed
US-20120295922-A1 Compounds For Use In Treatment Of Mucositis POLYMEDIX, INC. (US) 2012-11-22 — — US disclosed
US-20120258141-A9 Methods Of Immune Modulation UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) 2012-10-11 — — US disclosed
US-20120039945-A1 Methods Of Immune Modulation UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) 2012-02-16 — — US disclosed
US-20110178104-A1 Anti-Heparin Compounds POLYMEDIX INC. (US) 2011-07-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170224640-A1 Compounds For Use In Treatment Of Mucositis MUC1, FUT6, MMP8 NPY4R 4770/4885NPY1R 4756/4885ERAP2 646/4885
US-10603294-B2 Compounds for use in treatment of mucositis MUC1, FUT6, MMP8 NPY4R 4770/4885NPY1R 4756/4885ERAP2 646/4885
US-20140364364-A1 COMPOUNDS FOR USE IN TREATMENT OF MUCOSITIS MUC1, FUT6, MMP8 NPY4R 4770/4885NPY1R 4756/4885ERAP2 646/4885
US-20120295922-A1 Compounds For Use In Treatment Of Mucositis MUC1, FUT6, MMP8 NPY4R 4770/4885NPY1R 4756/4885ERAP2 646/4885
US-20120258141-A9 Methods Of Immune Modulation IFNG, CD14, TLR3 NPY4R 2324/4885NPY1R 3334/4885ERAP2 1201/4885
US-20120039945-A1 Methods Of Immune Modulation IFNG, CD14, TLR3 NPY4R 2324/4885NPY1R 3334/4885ERAP2 1201/4885
US-10206894-B2 Compounds for use in treatment of mucositis MUC1, FUT6, SI NPY4R 4874/4885NPY1R 4873/4885ERAP2 692/4885
US-20110178104-A1 Anti-Heparin Compounds SERPINC1, CFH, SERPINH1 NPY4R 3718/4885NPY1R 3602/4885ERAP2 325/4885
US-20190282521-A1 Compounds For Use In Treatment Of Mucositis MUC1, FUT6, MMP8 NPY4R 4770/4885NPY1R 4756/4885ERAP2 646/4885
US-20180064664-A1 Compounds For Use In Treatment of Mucositis MUC1, FUT6, SI NPY4R 4874/4885NPY1R 4873/4885ERAP2 692/4885
US-20160213668-A1 Compounds for use in Treatment of Mucostis MUC1, SOST, ALG1 NPY4R 3304/4885NPY1R 3190/4885ERAP2 1201/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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