Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1963 | 0.80 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1TSHRPKM | |
| SCHEMBL8399191 | 0.79 | MEN1 (0.48) | MEN1KMT2AALDH1A1TSHRPKM | |
| SCHEMBL7722774 | 0.77 | MEN1 (0.52) | MEN1KMT2AALDH1A1TSHRPKM | |
| SCHEMBL379262 | 0.76 | MEN1 (0.50) | MEN1KMT2AALDH1A1TSHRPKM | |
| SCHEMBL13622353 | 0.76 | MEN1 (0.41) | MEN1KMT2AALDH1A1TSHRPKM | |
| SCHEMBL17212019 | 0.76 | MEN1 (0.41) | MEN1KMT2AALDH1A1PKMKDM4E | |
| SCHEMBL14016347 | 0.76 | MEN1 (0.46) | MEN1KMT2AALDH1A1TSHRPKM | |
| SCHEMBL1313060 | 0.75 | CYP4F2 (0.47) | MEN1KMT2AALDH1A1TSHRPKM | |
| SCHEMBL9748657 | 0.75 | MMP8 (0.44) | MEN1KMT2AALDH1A1TSHRPKM | |
| SCHEMBL2410161 | 0.74 | MMP8 (0.49) | MEN1KMT2AALDH1A1TSHRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274316-B1 | LIGANDS OF ESTROGEN RECEPTORS AND , METHOD OF THEIR PREPARATION AND PHARMACEUTICALS COMPRISING THEM | USTAV MOLEKULARNI GENETIKY AV CR V V I (CZ) | 2013-02-13 | — | — | EP | disclosed |
| EP-2274316-B1 | LIGANDS OF ESTROGEN RECEPTORS AND , METHOD OF THEIR PREPARATION AND PHARMACEUTICALS COMPRISING THEM | USTAV MOLEKULARNI GENETIKY AV CR V V I (CZ) | 2013-02-13 | — | — | EP | disclosed |
| US-8334280-B2 | Ligands of estrogen receptors α and β, method of their preparation, and pharmaceuticals comprising them | Ustav Molekularni Genetikv AV CR, V.V.I. (CZ) | 2012-12-18 | — | — | US | disclosed |
| US-8334280-B2 | Ligands of estrogen receptors α and β, method of their preparation, and pharmaceuticals comprising them | Ustav Molekularni Genetikv AV CR, V.V.I. (CZ) | 2012-12-18 | — | — | US | disclosed |
| US-8334280-B2 | Ligands of estrogen receptors α and β, method of their preparation, and pharmaceuticals comprising them | Ustav Molekularni Genetikv AV CR, V.V.I. (CZ) | 2012-12-18 | — | — | US | disclosed |
| US-20110118225-A1 | Ligands of Estrogen Receptors alpha and beta, Method of Their Preparation, and Pharmaceuticals Comprising Them | UNIVERZITA KARLOVA V PRAZE, PRIRODOVEDECKA FAKULTA UK (CZ) | 2011-05-19 | — | — | US | disclosed |
| US-20110118225-A1 | Ligands of Estrogen Receptors alpha and beta, Method of Their Preparation, and Pharmaceuticals Comprising Them | UNIVERZITA KARLOVA V PRAZE, PRIRODOVEDECKA FAKULTA UK (CZ) | 2011-05-19 | — | — | US | disclosed |
| US-20110118225-A1 | Ligands of Estrogen Receptors alpha and beta, Method of Their Preparation, and Pharmaceuticals Comprising Them | UNIVERZITA KARLOVA V PRAZE, PRIRODOVEDECKA FAKULTA UK (CZ) | 2011-05-19 | — | — | US | disclosed |
| EP-2274316-A1 | LIGANDS OF ESTROGEN RECEPTORS AND , METHOD OF THEIR PREPARATION AND PHARMACEUTICALS COMPRISING THEM | Ustav Molekularni Genetiky Av Cr, V.v.i. (CZ) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009135449-A1 | LIGANDS OF ESTROGEN RECEPTORS α AND β, METHOD OF THEIR PREPARATION AND PHARMACEUTICALS COMPRISING THEM | USTAV MOLEKULARNI GENETIKY AV CR, V.V.I. (CZ) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009135449-A1 | LIGANDS OF ESTROGEN RECEPTORS α AND β, METHOD OF THEIR PREPARATION AND PHARMACEUTICALS COMPRISING THEM | USTAV MOLEKULARNI GENETIKY AV CR, V.V.I. (CZ) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118225-A1 | Ligands of Estrogen Receptors alpha and beta, Method of Their Preparation, and Pharmaceuticals Comprising Them | ESR2, GPER1, ESRRB | MEN1 3851/4885KMT2A 4035/4885ALDH1A1 1217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.