Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | CASP1 | P29466 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3990274 | 0.89 | MAPT (0.47) | MAPTTDP1ALOX15SLC7A5CA12 | |
| SCHEMBL3990269 | 0.87 | MAPT (0.46) | MAPTTDP1ALOX15SLC7A5CA12 | |
| SCHEMBL1028144 | 0.86 | ALOX15 (0.48) | MAPTTDP1ALOX15SLC7A5CA12 | |
| SCHEMBL11090176 | 0.86 | ALOX15 (0.53) | MAPTTDP1ALOX15SLC7A5CA12 | |
| SCHEMBL13948752 | 0.84 | GABRA1 (0.48) | MAPTTDP1ALOX15SLC7A5CA12 | |
| SCHEMBL1121892 | 0.83 | ALOX15 (0.51) | MAPTTDP1ALOX15SLC7A5CA12 | |
| SCHEMBL23093930 | 0.81 | ALOX15 (0.50) | MAPTTDP1ALOX15SLC7A5CA12 | |
| SCHEMBL2686416 | 0.81 | ALOX15 (0.50) | MAPTTDP1ALOX15SLC7A5CA12 | |
| SCHEMBL17184949 | 0.81 | CA12 (0.47) | ALOX15SLC7A5CA12CA1CA2 | |
| SCHEMBL277597 | 0.81 | GABRA1 (0.49) | MAPTALOX15SLC7A5CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530221-B2 | Pyrimido[4,5-d]pyrimidin-2-one derivatives as protein kinase inhibitors | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2022-12-20 | — | — | US | disclosed |
| US-11530221-B2 | Pyrimido[4,5-d]pyrimidin-2-one derivatives as protein kinase inhibitors | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2022-12-20 | — | — | US | disclosed |
| EP-3253749-B1 | COMPOUNDS WITH ANTI-TUMORAL ACTIVITY | AB SCIENCE (FR) | 2021-12-08 | — | — | EP | disclosed |
| EP-3253749-B1 | COMPOUNDS WITH ANTI-TUMORAL ACTIVITY | AB SCIENCE (FR) | 2021-12-08 | — | — | EP | disclosed |
| CN-112442105-A | Novel pyrimido [4,5-d ] pyrimidin-2-one derivatives as protein kinase inhibitors | 韩国科学技术研究院 | 2021-03-05 | — | — | CN | disclosed |
| US-20210061810-A1 | PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2021-03-04 | — | — | US | disclosed |
| US-20210061810-A1 | PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2021-03-04 | — | — | US | disclosed |
| WO-2021040422-A1 | NOVEL PYRIMIDO[4,5-D]PYRIMIDINE-2-ONE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY | 한국과학기술연구원 | 2021-03-04 | — | — | WO | disclosed |
| WO-2021040422-A1 | NOVEL PYRIMIDO[4,5-D]PYRIMIDINE-2-ONE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY | 한국과학기술연구원 | 2021-03-04 | — | — | WO | disclosed |
| EP-3053920-B1 | COMPOUNDS WITH ANTI-TUMORAL ACTIVITY | AB SCIENCE (FR) | 2020-04-08 | — | — | EP | disclosed |
| EP-2953457-A2 | ERK INHIBITORS AND USES THEREOF | Celgene Avilomics Research, Inc. (US) | 2015-12-16 | — | — | EP | disclosed |
| US-9145387-B2 | ERK inhibitors and uses thereof | CELGENE AVILOMICS RESEARCH, INC. (US) | 2015-09-29 | — | — | US | disclosed |
| WO-2014124230-A2 | ERK INHIBITORS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2014-08-14 | — | — | WO | disclosed |
| US-20140228322-A1 | ERK INHIBITORS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2014-08-14 | — | — | US | disclosed |
| US-8513235-B2 | Homocysteine synthase inhibitor | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-08-20 | — | — | US | disclosed |
| EP-2486925-A1 | THERAPEUTIC AGENT FOR CEREBRAL INFARCTION | Mitsubishi Tanabe Pharma Corporation (JP) | 2012-08-15 | — | — | EP | disclosed |
| US-20120196824-A1 | THERAPEUTIC AGENT FOR CEREBRAL INFARCTION | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-08-02 | — | — | US | disclosed |
| US-20110034440-A1 | HOMOCYSTEINE SYNTHASE INHIBITOR | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-02-10 | — | — | US | disclosed |
| EP-2275404-A1 | HOMOCYSTEINE SYNTHASE INHIBITOR | Mitsubishi Tanabe Pharma Corporation (JP) | 2011-01-19 | — | — | EP | disclosed |
| US-4070353-A | FOR PLASTICS AND PRINTING INKS, YELLOW TO ORANGE SHADES | CIBA-GEIGY CORPORATION (US) | 1978-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11530221-B2 | Pyrimido[4,5-d]pyrimidin-2-one derivatives as protein kinase inhibitors | LCK, CDK2, CDK5 | MAPT 2881/4885TDP1 1101/4885ALOX15 3795/4885 |
| US-20120196824-A1 | THERAPEUTIC AGENT FOR CEREBRAL INFARCTION | FABP7, TIMP3, MMP11 | MAPT 230/4885TDP1 4245/4885ALOX15 796/4885 |
| US-20110034440-A1 | HOMOCYSTEINE SYNTHASE INHIBITOR | BHMT, CBS, BHMT2 | MAPT 1767/4885TDP1 744/4885ALOX15 933/4885 |
| US-20210061810-A1 | PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | LCK, CDK2, CDK5 | MAPT 2218/4885TDP1 939/4885ALOX15 3991/4885 |
| US-20140228322-A1 | ERK INHIBITORS AND USES THEREOF | MAP3K20, MAP3K1, MAPK3 | MAPT 1618/4885TDP1 2390/4885ALOX15 3665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.