Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.57 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.57 |
| ▸ | HTR1F | P30939 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.56 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | YAP1 | P46937 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13592382 | 0.90 | MAPT (0.68) | MAPTCARM1PRMT6KMT2AMEN1 | |
| SCHEMBL20069165 | 0.81 | PKM (0.74) | MAPTCARM1PRMT6KMT2AALDH1A1 | |
| SCHEMBL10212156 | 0.81 | PKM (0.74) | MAPTCARM1PRMT6KMT2AALDH1A1 | |
| SCHEMBL2013270 | 0.81 | KMT2A (0.59) | MAPTNPC1RAB9AKMT2AKCNK3 | |
| SCHEMBL18754208 | 0.81 | CARM1 (0.57) | MAPTCARM1PRMT6KMT2AMEN1 | |
| SCHEMBL19302972 | 0.80 | ALDH1A1 (0.69) | MAPTALDH1A1SMN1; SMN2GAAPKM | |
| SCHEMBL5216542 | 0.79 | HTR1F (0.82) | NPC1RAB9AHTR1FKMT2AKCNK3 | |
| SCHEMBL10131252 | 0.79 | LMNA (0.60) | MAPTKMT2AALDH1A1MEN1PKM | |
| SCHEMBL30828601 | 0.77 | POLB (0.58) | NPC1RAB9A | |
| Oxalic Acid SCHEMBL5208197 | 0.77 | HTR1F (0.79) | NPC1RAB9AHTR1FKMT2AKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3621958-B1 | PHOTOCHROMIC INDENO FUSED PHENANTHRENOPYRAN COMPOUNDS | TRANSITIONS OPTICAL LTD (IE) | 2024-07-10 | — | — | EP | disclosed |
| EP-3268375-B1 | PHOTOCHROMIC THIENOCHROMENE COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2022-06-15 | — | — | EP | disclosed |
| EP-3071576-B9 | PHOTOCHROMIC INDENO-FUSED RING PYRAN COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2021-12-22 | — | — | EP | disclosed |
| EP-3071576-B1 | PHOTOCHROMIC INDENO-FUSED RING PYRAN COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2021-08-18 | — | — | EP | disclosed |
| US-20200048216-A1 | Photochromic Indeno Fused Phenanthrenopyran Compounds | TRANSITIONS OPTICAL, LTD. (IE) | 2020-02-13 | — | — | US | disclosed |
| EP-2370420-B9 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2019-11-13 | — | — | EP | disclosed |
| EP-2370420-B1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2019-05-22 | — | — | EP | disclosed |
| EP-2357217-B9 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2019-03-13 | — | — | EP | disclosed |
| EP-3071550-B1 | METHOD OF PREPARING FUSED RING INDENO COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2019-03-13 | — | — | EP | disclosed |
| US-10005763-B2 | Photochromic compounds | TRANSITIONS OPTICAL, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-20080096049-A1 | capable of switching between the two states in response to at least actinic radiation; thermally reversible | TRANSITIONS OPTICAL, INC. (US) | 2008-04-24 | — | — | US | disclosed |
| US-20080096049-A1 | capable of switching between the two states in response to at least actinic radiation; thermally reversible | TRANSITIONS OPTICAL, INC. (US) | 2008-04-24 | — | — | US | disclosed |
| US-20080096048-A1 | Thermally reversible; absorption ratio greater than 2.3 | TRANSITIONS OPTICAL, INC. (US) | 2008-04-24 | — | — | US | disclosed |
| US-20080096048-A1 | Thermally reversible; absorption ratio greater than 2.3 | TRANSITIONS OPTICAL, INC. (US) | 2008-04-24 | — | — | US | disclosed |
| US-7342112-B2 | Photochromic compounds | PPG INDUSTRIES OHIO, INC. (US) | 2008-03-11 | — | — | US | disclosed |
| US-7342112-B2 | Photochromic compounds | PPG INDUSTRIES OHIO, INC. (US) | 2008-03-11 | — | — | US | disclosed |
| US-20080051575-A1 | capable of switching between the two states in response to at least actinic radiation; thermally reversible | TRANSITIONS OPTICAL ,INC. (US) | 2008-02-28 | — | — | US | disclosed |
| US-20080051575-A1 | capable of switching between the two states in response to at least actinic radiation; thermally reversible | TRANSITIONS OPTICAL ,INC. (US) | 2008-02-28 | — | — | US | disclosed |
| US-20080045704-A1 | Thermally reversible; absorption ratio greater than 2.3; cell method | TRANSITIONS OPTICAL, INC. (US) | 2008-02-21 | — | — | US | disclosed |
| US-20080045704-A1 | Thermally reversible; absorption ratio greater than 2.3; cell method | TRANSITIONS OPTICAL, INC. (US) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048216-A1 | Photochromic Indeno Fused Phenanthrenopyran Compounds | ALDH1A2, RB1, INCENP | MAPT 1822/4885NPC1 3498/4885RAB9A 3935/4885 |
| US-20080045704-A1 | Thermally reversible; absorption ratio greater than 2.3; cell method | CCND3, CCND1, CCND2 | MAPT 4145/4885NPC1 4709/4885RAB9A 3848/4885 |
| US-20080096048-A1 | Thermally reversible; absorption ratio greater than 2.3 | CCND1, CCND3, CCND2 | MAPT 4150/4885NPC1 4806/4885RAB9A 3999/4885 |
| US-10005763-B2 | Photochromic compounds | CCR4, CCR8, CBR3 | MAPT 3402/4885NPC1 2905/4885RAB9A 2043/4885 |
| US-20080051575-A1 | capable of switching between the two states in response to at least actinic radiation; thermally reversible | CCND1, CCND2, CCNE1 | MAPT 4085/4885NPC1 4879/4885RAB9A 3306/4885 |
| US-20080096049-A1 | capable of switching between the two states in response to at least actinic radiation; thermally reversible | CCND1, CCND2, CCNE1 | MAPT 4085/4885NPC1 4879/4885RAB9A 3306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.