Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 2/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 7/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 7/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10324422 | 0.89 | DGAT1 (0.43) | MELKFFAR4SCD | |
| SCHEMBL10326401 | 0.89 | MELK (0.39) | MELKFFAR4GRIN2B | |
| SCHEMBL10380728 | 0.80 | FFAR4 (0.43) | AOC3FFAR4GPR119GRIN2B | |
| SCHEMBL10325542 | 0.78 | GPR119 (0.37) | AOC3TNFGPR119 | |
| SCHEMBL10325755 | 0.76 | AOC3 (0.33) | AOC3FFAR4GPR119 | |
| SCHEMBL10325123 | 0.75 | KDM4E (0.46) | MELKGRIN2B | |
| SCHEMBL17729168 | 0.69 | IDO1 (0.54) | — | |
| SCHEMBL10380233 | 0.69 | FFAR4 (0.41) | FFAR4GRIN2B | |
| SCHEMBL14967451 | 0.65 | GRIN2B (0.41) | MELKFFAR4GRIN2B | |
| SCHEMBL1976988 | 0.64 | AKR1C3 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012096813-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-07-19 | — | — | WO | disclosed |